Browsing by Author "Pretorius, Ashley"
Now showing items 1-18 of 18
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Analysis, expression profiling and characterization of hsa-miR-5698 target genes as putative dynamic network biomarkers for prostate cancer: a combined in silico and molecular approach
Lombe, Chipampe Patricia (University of the Western Cape, 2019)2018, the International Agency for Research on Cancer (IARC) estimated that prostate cancer (PCa) was the second leading cause of death in males worldwide. The number of deaths are expected to raise by 50 % in the next ... -
Characterization of ATP-binding cassette drug transporters and their role in breast cancer treatment using in silico approach
Hassan, Mohammed Hashim Abdalraheem (University of the Western Cape, 2019)Breast cancer is the most common cancer in women worldwide, and is the second most common cancer in the world, responsible for more than 500 000 deaths annually. Estimates are that 1 in 8 women will develop breast cancer ... -
The detection of meningococcal disease through identification of antimicrobial peptides using an in silico model creation
Abdullah, Gadija (University of the Western Cape, 2019)Neisseria meningitidis (the meningococcus), the causative agent of meningococcal disease (MD) was identified in 1887 and despite effective antibiotics and partially effective vaccines, Neisseria meningitidis (N. meningitidis) ... -
Functional analysis of miRNA regulated genes in prostate cancer as potential diagnostic molecules
Abdullah, Gadija (University of the Western Cape, 2016)Prostate Cancer is the leading cause of cancer-related death in males in the Western world. It is a common biological disease originating from the reproductive system of the male namely, the prostate gland, usually in older ... -
Functional analysis of the mouse RBBP6 gene using Interference RNA
Pretorius, Ashley (University of the Western Cape, 2007)The aim of this thesis was to investigate the cellular role of the mouse RBBP6 gene using the interference RNA (RNAi) gene targeting technology and also to understand the relevance of two promoters for the RBBP6 gene. -
Identification and Molecular validation of Biomarkers for the accurate and sensitive diagnosis of bacterial and viral Pneumonia
Bakare, Olalekan Olanrewaju (University of Western Cape, 2019)Pneumonia remains the major cause of death in children and the elderly and several efforts have been intensified to reduce the rate of pneumonia infection. The major breakthrough has been the discovery of certain biomarkers ... -
Identification and validation of micrornas for diagnosing type 2 diabetes : an in silico and molecular approach
Anthony, Yancke (University of the Western Cape, 2015)Type 2 diabetes mellitus (T2DM), a metabolic disease characterized by chronic hyperglycemia, is the most prevalent form of diabetes globally, affecting approximately 95 % of the total number of people with diabetes i.e. ... -
Identification and validation of putative therapeutic and diagnostic antimicrobial peptides against HIV: An in silico approach
Tincho, Marius Belmondo (University of the Western Cape, 2013)Background: Despite the effort of scientific research on HIV therapies and to reduce the rate of HIV infection, AIDS still remains one of the major causes of death in the world and mostly in Sub-Saharan Africa. To date, ... -
Identification of biomarkers associated with cervical cancer: a combined in silico and molecular approach
Ludaka, Namhla (University of the Western Cape, 2014)Cervical cancer is the leading cause of cancer mortality among black women in South Africa. It is estimated that this disease kills approximately 8 women in South Africa every day. Cervical cancer is caused by the human ... -
Identification of microRNAs as a class of biomarkers for the early diagnosis of prostate cancer : an in silico and molecular approach
Lombe, Chipampe Patricia (University of the Western Cape, 2015)Prostate cancer (PCa) is the second most common form of cancer in men around the world. In many parts of Africa, data on prostate cancer is sparse. This is attributed to poor access to testing and diagnostics. The ... -
Identification of miRNA's as specific biomarkers in prostate cancer diagnostics : a combined in silico and molecular approach
Khan, Firdous (University of the Western Cape, 2015)There are over 100 different types of cancer, and each of these cancers are classified by the type of cell that it initially affects. For the purpose of this research we will be focussing on prostate cancer (PC). Prostate ... -
Identification of novel miRNAs as diagnostic and prognostic biomarkers for prostate cancer using an in silico approach
Eshibona, Nasr O.M. (University of the Western Cape, 2017)Cancer is known as uncontrollable cell growth which results in the formation of tumours in the areas that are affected by the cancer. There are two types of tumours: benign and malignant. This study focus is on prostate ... -
Identification of novel miRNAs as diagnostic molecules for detection of breast cancer using in silico approaches
Ferrara, Najua Ali (University of the Western cape, 2017)Breast cancer (BC) is the most common cancer in women worldwide, and is the second most common cancer in the world, responsible for more than 500 000 deaths annually. Estimates are that 1 in 8 women will develop BC in their ... -
Identification of potential biomarkers in lung cancer as possible diagnostic agents using bioinformatics and molecular approaches
Ahmed, Firdous (University of the Western Cape, 2015)Lung cancer remains the leading cause of cancer deaths worldwide, with the majority of cases attributed to non-small cell lung carcinomas. At the time of diagnosis, a large percentage of patients present with advanced stage ... -
In silico and molecular validation of identified putative genes and functional analysis of a N K G2D ligand as a breast cancer biomarkers
Bankole, Habeeb Adebodun (University of the Western Cape, 2015)The current diagnostic, prognostic, predictive and therapeutic monitoring methods used for breast cancer are limited. Thus, research into more specific, sensitive and effective strategies is required. Breast cancer is ... -
MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches
Fadaka, Adewale Oluwaseun (University of the Western Cape, 2019)Colorectal cancer (CRC) is referred to as cancers that arise in the colon or rectum. Rectal cancer is most often defined as cancers originating within 15 cm from the anal verge. The crude incidence of CRC in sub-Sahara ... -
Single nucleotide polymorphism association studies of ABCA13 and ABHD11 genes and the bioinformatics analysis of the autism candidate genes localized on chromosome 7
Davids, Muneera (University of the Western Cape, 2016)Autism, Aspergers Syndrome and Pervasive Developmental Delay-Not Otherwise Specified (PDD-NOS), among others, fall under an umbrella of disorders known as Autism Spectrum Disorder. Twin studies show that autism is a highly ... -
The molecular validation of miRNA's as specific biomarkers for early diagnosis of ovarian cancer
Lottering, Sharneal (University of the Western Cape, 2017)Ovarian Cancer (OC) is the most common reproductive and the most lethal gynaecological malignant tumour. The majority of Ovarian Cancers, comprising more than 95% of cases, emanate from the surface epithelium of the ovary, ...