dc.contributor.advisor | Tiffin, Nicki | |
dc.contributor.author | van Vuuren, Larry Peter | |
dc.date.accessioned | 2018-07-30T10:13:09Z | |
dc.date.available | 2018-08-31T22:10:06Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://hdl.handle.net/11394/6122 | |
dc.description | Philosophiae Doctor - PhD (Bioinformatics) | |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease
characterized by the production of a wide range of autoantibodies directed against selfantigens.
SLE can influence almost any organ system and its appearance and course are
highly varied, ranging from remission to disease flare. SLE demonstrates a variety of
constitutional symptoms, such as the skin, musculoskeletal and mild hematologic
involvement. On the other hand, some patients present with primarily hematologic, renal or
neuropsychiatric manifestations. | |
dc.language.iso | en | |
dc.publisher | University of the Western Cape | |
dc.title | Identification of coding variants associated
with familial systemic lupus erythematosus
through whole exome sequencing | |
dc.rights.holder | University of the Western Cape | |