Ethionamide pharmacokinetics in multidrugresistant tuberculosis patients with and without HIVinfection
Abstract
Many studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs
in tuberculosis patients. However, currently in South Africa, no studies have been
done on ethionamide (ETH) PK in adult MDR-TB patients that are infected with HIV
and those without HIV infection. Therefore, the objective of this current study was
firstly, to find out ethionamide plasma concentration using the LC-MS method;
secondly, to evaluate and compare the pharmacokinetics of ethionamide in MDR-TB
patients infected with and without HIV infection; thirdly, to examine the effects of
ARVs and kidney impairment on the PK of ethionamide and fourthly, to find out the
consequence of sex and age on ETH PK parameters.