Show simple item record

dc.contributor.advisorPool, Edmund
dc.contributor.advisorFidalgo, M.
dc.contributor.authorAlgadi, Hend Emhemed
dc.date.accessioned2019-09-02T10:06:57Z
dc.date.available2019-09-02T10:06:57Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/11394/6983
dc.descriptionMagister Scientiae (Medical Bioscience) - MSc(MBS)en_US
dc.description.abstractGraphene oxide (GO) is a single carbon layer, oxygen bearing graphene derivative, containing hydroxyl and carboxyl groups. Graphene oxide nanoparticles (GONPs) are promising nanomaterials for a variety of applications such as electrochemical analysis, adsorption of biomolecules, biosensors and drug and vaccine delivery systems. While these newly engineered nanoparticles hold great potential for developments in industry and medicine, the widespread use of these material will inevitably result in GO residues in the environment where they could possibly pose a risk to human and wildlife health. Interaction of the nanoparticles and biota can affect numerous biological processes. In humans they can affect any of the physiological systems such as the immune, endocrine, reproductive and cardiovascular systems. Although studies have indicated that GO exposure cause increased reactive oxygen species in cells, they mechanisms whereby GO act on the cell are still poorly understood. A few studies have investigated the effects of GONP and other graphene nanoparticle derivatives on the immune system. The aim of this study was to investigate the in vitro effects of GONPs on the immune system by the exposure of the murine macrophage cell line, RAW 264.7, to different concentrations of GONPs.en_US
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.subjectGraphene oxide nanoparticlesen_US
dc.subjectCytotoxicityen_US
dc.subjectCell-mediated immunityen_US
dc.subjectCytokinesen_US
dc.subjectImmunotoxicityen_US
dc.titleEffects of graphene oxide nanoparticles on the immune system biomarkers produced by RAW 264.7en_US
dc.rights.holderUniversity of the Western Capeen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record