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dc.contributor.advisorHiss, Donavon
dc.contributor.authorElakrout, Alhussien Ali
dc.date.accessioned2019-09-03T12:12:38Z
dc.date.available2019-09-03T12:12:38Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/11394/6993
dc.descriptionPhilosophiae Doctor - PhDen_US
dc.description.abstractThe emergence of virulent and drug-resistant bacterial strains such as methicillin-resistant Staphylococcus aureus (MRSA) is a global public health burden. The World Health Organization (WHO) has placed MRSA and vancomycin-intermediate-sensitive S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) on a high global priority pathogens list of antibiotic-resistant bacteria to promote the research and development of novel and effective antibiotic therapeutic rationales. Uncomplicated S. aureus bacteraemia (e.g., mild skin infections) may be treatable with the conventional regimens of antibiotics, but resistance strains of the bacteria (e.g., invasive infections), often persist as a high load of bacterial DNA in blood, and has been linked to increased mortality in world populations, irrespective of country or location. Several lines of evidence imply that combinations of vancomycin (a glycopeptide antibiotic that targets cell wall synthesis) and ß-lactam antibiotics that target the penicillin-binding proteins (PBPs) improve clearance of MRSA bloodstream infections (BSIs).en_US
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.subjectAntimicrobial Resistanceen_US
dc.subjectBrain-Heart Infusion Brothen_US
dc.subjectLibyaen_US
dc.subjectPhenotypicen_US
dc.subjectMethicillin-resistanten_US
dc.titlePhenotypic and molecular characteristics of Methicillin-resistant Staphylococcus Aureus isolates from stored patient samples in Misurata hospitals and poultry from commercial markets, Libyaen_US
dc.rights.holderUniversity of the Western Capeen_US


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