Browsing Faculty of Natural Science by Title
Now showing items 407-426 of 2547
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Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer
(University of the Western Cape, 2015)Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a ... -
Computational characterisation of DNA methylomes in mycobacterium tuberculosis Beijing hyper- and hypo-virulent strains
(University of the Western Cape, 2014)Mycobacterium tuberculosis, the causative agent of tuberculosis, is estimated to infect approximately one-third of the world’s population and is responsible for around 2 million deaths per year. The disease is endemic in ... -
A computational characterisation of the relationship between genome structure and disease genes
(University of the Western Cape, 2012)This is a pilot study to investigate the relationship between disease gene status and the structure of the human genome with specific reference to regions of recombination. It compares certain characteristics of a control ... -
Computational characterization of IRE-regulated genes in Glossina morsitans
(University of Western Cape, 2013)Blood feeding is a habit exhibited by many insects. Considering the devastating impact of these insects on human health, it is important to focus research on understanding the biology behind blood-feeding, disease ... -
A computational framework for transcriptome assembly and annotation in non-model organisms: the case of venturia inaequalis
(University of the Western Cape, 2014)In this dissertation three computational approaches are presented that enable optimization of reference-free transcriptome reconstruction. The first addresses the selection of bona fide reconstructed transcribed fragments ... -
Computational genomics approaches for kidney diseases in Africa
(University of the Western Cape, 2015)End stage renal disease (ESRD), a more severe form of kidney disease, is considered to be a complex trait that may involve multiple processes which work together on a background of a significant genetic susceptibility. ... -
Computational modelling of a hot-wire chemical vapour deposition reactor chamber
(University of Western Cape, 2020)In this thesis, I explore the subjects of fluid dynamics and the Hot-Wire Chemical Vapour Deposition (HWCVD) process. HWCVD, in its simplicity, is one of the more powerful and elegant deposition techniques available in ... -
Computational prediction of host-pathogen protein-protein interactions
(University of the Western Cape, 2017)Supervised machine learning approaches have been applied successfully to the prediction of protein-protein interactions (PPIs) within a single organism, i.e., intra-species predictions. However, because of the absence of ... -
Computational strategies to identify, prioritize and design potential antimalarial agents from natural products
(University of the Western Cape, 2015)Introduction: There is an exigent need to develop novel antimalarial drugs in view of the mounting disease burden and emergent resistance to the presently used drugs against the malarial parasites. A large amount of natural ... -
Computational verification of published human mutations
(University of the Western Cape, 2008)The completion of the Human Genome Project, a remarkable feat by any measure, has provided over three billion bases of reference nucleotides for comparative studies. The next, and perhaps more challenging step is to analyse ... -
Computing Mislin genera of certain groups with non-abelian torsion radicals
(University of the Western Cape, 2004)In this mini-thesis we present some generalities of non-cancellation and localization and we compute non-cancellation groups. We consider groups belonging to the class X0 of all finitely generated groups that have finite ... -
Concept Based Knowledge Discovery from Biomedical Literature
(University of the Western Cape, 2009)This thesis describes and introduces novel methods for knowledge discovery and presents a software system that is able to extract information from biomedical literature, review interesting connections between various ... -
Concept Based Knowledge Discovery From Biomedical Literature
(University of the Western Cape, 2009)Advancement in biomedical research and continuous growth of scientific literature available in electronic form, calls for innovative methods and tools for information management, knowledge discovery, and data integration. ... -
A conceptual understanding of groundwater recharge processes and surface-water/ groundwater interactions in the Kruger National Park
(University of the Western Cape, 2012)In the Kruger National Park (KNP) which is the flagship conservation area in South Africa, the impact on groundwater should be kept to a minimum as groundwater plays a vital role in sustaining ecosystem functioning and ... -
Conceptualization of urban hydrogeology within the context of water sensitive urban design: case study of Cape Flats Aquifer
(University of the Western Cape, 2018)Urban hydrogeology can be used to facilitate a decision-making process regarding the implementation of water sensitive urban design (WSUD) to manage water systems of periurban cities. This thesis was aimed at providing ... -
Conjugacy classes of some projective linear groups
(University of the Western Cape, 1992)Given a finite set X of distinct symbols the symmetric group Sx and the alternating group Ax are obtained without further constructions. More interesting groups are contrived, however, by imposing a certain structure on ... -
Conjugacy classes of some projective linear groups
(University of the Western Cape, 1992)Given a finite set X of distinct symbols the symmetric group S* and the alternating group A* are obtained without further constructions. More interesting groups are contrived, however, by imposing a certain structure on ... -
Conservation and resource-use relations: Analysis for protected area expansion feasibility in the Western Cape
(University of the Western Cape, 2022)It is assumed that expanding the size and/or number of protected and conservation areas can contribute to more effective conservation, ecosystem services and environmental protection. Expansion is normally a response to ... -
Consolidated nanomaterials synthesized using nickel micro-wires and carbon nanotubes
(University of the Western Cape, 2007)Nano-devices are the next step in the application of nanomaterials in modern technology. One area of research that is receiving an increased amount of attention globally is the fabrication of new nano-devices for applications ... -
Constraining the stratigraphy and paleotectonic development of the Cango Caves and Kansa Groups (Western Cape, South Africa) using detrital zircon and whole-rock geochemistry
(University of the Western Cape, 2022)The Saldania Belt is a Neoproterozoic to early Paleozoic low-grade orogenic belt that borders the southern and southwestern margins of the Kalahari Carton. It forms part of the Neoproterozoic Pan-African and Brasiliano ...