Browsing Faculty of Natural Science by Author "Hide, Winston"
Now showing items 1-20 of 20
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Ancient Genes in Cancer Gene Expression?
Panji, Sumir (University of the Western Cape, 2004)Backsround: The Cancer/testis (CT) antigens are a division of germ cell specific genes not expressed in somatic cells, exceptions being placental cells and 20Vo - 4OVo of cancer types. The aptitude of CT antigens to elicit ... -
Assessment of genome visualization tools relevant to HIV genome research: development of a genome browser prototype
Boardman, Anelda Philine (University of the Western Cape, 2004)Over the past two decades of HIV research, effective vaccine candidates have been elusive. Traditionally viral research has been characterized by a gene -by-gene approach, but in the light of the availability of complete ... -
A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
Mpondo, Feziwe (2009)Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly ... -
A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
Mpondo, Feziwe (University of the western cape, 2009)Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly ... -
Detection of positive selection resulting from Nevirapine treatment in longitudinal HIV-1 reverse transcriptase sequences
Ketwaroo, Bibi Farahnaz K. (University of the Western Cape, 2006)Nevirapine (NVP) is a cheap anti-retroviral drug used in poor countries worldwide, administered to pregnant women at the onset of labour to inhibit HIV enzyme reverse transcriptase. Viruses which may get transmitted to ... -
The development and application of informatics-based systems for the analysis of the human transcriptome
Kelso, Janet (University of the Western Cape, 2003)Despite the fact that the sequence of the human genome is now complete it has become clear that the elucidation of the transcriptome is more complicated than previously expected. There is mounting evidence for unexpected ... -
Development and implementation of ontology-based systems for mammalian gene expression profiling
Kruger, Adéle (2009)The use of ontologies in the mapping of gene expression events provides an effective and comparable method to determine the expression profile of an entire genome across a large collection of experiments derived from ... -
Development and implementation of ontology-based systems for mammalian gene expression profiling
Kruger, Adele (University of the Western Cape, 2009)The use of ontologies in the mapping of gene expression events provides an effective and comparable method to determine the expression profile of an entire genome across a large collection of experiments derived from ... -
"Development and implementation of ontology-based systems for mammalian gene expression profiling"
Kruger, Adele (University of the Western Cape, 2009)The use of ontologies in the mapping of gene expression events provides an effective and comparable method to determine the expression profile of an entire genome across a large collection of experiments derived from ... -
The genease activity of mung bean nuclease: fact or fiction?
Kula, Nothemba (University of the Western Cape, 2004)The action of Mung Bean Nuclease (MBN) on DNA makes it possible to clone intact gene fragments from genes of the malaria parasite, Plasmodium. This “genease” activity has provided a foundation for further ... -
Generation of a human gene index and its application to disease candidacy
Christoffels, Alan (University of the Western Cape, 2001)With easy access to technology to generate expressed sequence tags (ESTs), several groups have sequenced from thousands to several thousands of ESTs. These ESTs benefit from consolidation and organization to deliver ... -
HIV subtype C diversity: analysis of the relationship of sequence diversity to proposed epitope locations
Ernstoff, Elana Ann (University of the Western Cape, 2002)Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIVÂ’s biology and rapid mutation rate have made vaccine ... -
HIV Subtype C Diversity: Analysis of the Relationship of Sequence Diversity to Proposed Epitope Locations
Ernstoff, Elana Ann (University of the Western Cape, 2002)Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIV's biology and rapid mutation rate have made vaccine ... -
Identification of bacterial pathogenic gene classes subject to diversifying selection
Panji, Sumir (University of the Western Cape, 2009)Availability of genome sequences for numerous bacterial species comprising of different bacterial strains allows elucidation of species and strain specific adaptations that facilitate their survival in widely fluctuating ... -
Low detection of exon skipping in mouse genes orthologous to human genes on chromosome 22
Chern, Tzu-Ming (University of the Western Cape, 2002)Alternative RNA splicing is one of the leading mechanisms contributing towards transcript and protein diversity. Several alternative splicing surveys have confirmed the frequent occurrence of exon skipping in human genes. ... -
New algorithms for EST clustering
Ptitsyn, Andrey (University of the Western Cape, 2000)Summary: Expressed sequence tag database is a rich and fast growing source of data for gene expression analysis and drug discovery. Clustering of raw EST data is a necessary step for further analysis and one of the most ... -
New Algorithms for EST clustering
Ptitsyn, Andrey (University of the Western Cape, 2000)Expressed sequence tag database is a rich and fast growing source of data for gene expression analysis and drug discovery. Clustering of raw EST data is a necessary step for further analysis and one of the most challenging ... -
Novel genomic approaches for the identification of virulence genes and drug targets in pathogenic bacteria
Gamieldien, Junaid (University of the Western Cape, 2001)While the many completely sequenced genomes of bacterial pathogens contain all the determinants of the host-pathogen interaction, and also every possible drug target and recombinant vaccine candidate, computational tools ... -
Synergistic use of promoter prediction algorithms: A choice for small training dataset?
Oppon, Ekow CruickShank (University of the Western Cape, 2000)This chapter outlines basic gene structure and how gene structure is related to promoter structure in both prokaryotes and eukaryotes and their transcription machinery. An in-depth discussion is given on variations types ... -
Synergistic use of promoter prediction algorithms: a choice of small training dataset?
Oppon, Ekow CruickShank (University of the Western Cape, 2000)Promoter detection, especially in prokaryotes, has always been an uphill task and may remain so, because of the many varieties of sigma factors employed by various organisms in transcription. The situation is made more ...