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Functional analysis of the mouse RBBP6 gene using Interference RNA
(University of the Western Cape, 2007)
The aim of this thesis was to investigate the cellular role of the mouse RBBP6 gene using the interference RNA (RNAi) gene targeting technology and also to understand the relevance of two promoters for the RBBP6 gene.
Identification and characterisation of a novel gene, DWNN, isolated from promoter-trapped Chinese hamster ovary cells
(University of the Western Cape, 2005)
The process of cytotoxic T lymphocyte (CTL) killing involves the recognition and destruction of foreign antigens by cytotoxic T cells and is of crucial importance to the defence of the organism against viral infections. ...
In silico and molecular validation of identified putative genes and functional analysis of a N K G2D ligand as a breast cancer biomarkers
(University of the Western Cape, 2015)
The current diagnostic, prognostic, predictive and therapeutic monitoring methods
used for breast cancer are limited. Thus, research into more specific, sensitive and
effective strategies is required. Breast cancer is ...
The integrated effects of selected inducers of endoplasmic reticulum stress, the unfolded protein response and apoptosis on P-Glycoprotein mediated drug resistance in MCF-7 breast carcinoma cells
(University of the Western Cape, 2015)
Purpose: One of the leading causes of death reported in women worldwide is breast cancer. Manytumours, including breast cancer, associated with poor prognosis, have received a renewed focus and increased perspective with ...
Investigating novel cis-acting regulatory elements involved in the regulation of heat shock response in cardiomyocytes
(2013)
Ischemic heart disease is a disease which is characterized by the reduced blood
supply to the heart. According to WHO 2013, ischemic heart disease is one of the
major causes of death globally. For this reason, it is ...
Effect of Eurycoma longifolia (Tongkat Ali) on the prostate cancer cell line LNCaP
(2013)
Eurycoma Longfolia Jack, also known as Tongkat Ali (TA) is a tropical plant
belonging to the family of Simaroubaceae is widely distributed in South East Asian countries. The extracts of TA have been proven to have ...
Biochemical investigation of anti-cancer activity of Tulbaghia violacea
(UWC, 2012)
Natural products have been a source of many pharmaceutical drugs and a number of drugs that are currently used in the treatment of cancer are derivatives of compounds originally isolated from natural products. There is ...
Chemical and biological evaluation of palythoa tuberculosa collected from the red sea
(University of the Western Cape, 2015)
A chemical study on the total extract of the zoanthid Palythoa tuberculosa, collected
from the Red Sea, resulted in the isolation of seven polyhydroxylated sterols viz:
palysterols A-G, six of which are new. Their chemical ...
Investigation of anti-cancer potential of Pleiocarpa pycnantha leaves
(University of the Western Cape, 2013)
The Apocynaceae family is well known for its potential anticancer activity. Pleiocarpamine isolated from the Apocynaceae family and a constituent of Pleiocarpa pycnantha has been reported for anti-cancer activity. Prompted ...
Deciphering a potential cytoprotective role of novel heat shock responsive proteins using a proteomic approach
(University of the Western Cape, 2011)
Myocardial infarction, commonly known as a heart attack, is a condition where the blood supply to the heart tissue is cut off, starving the tissue from oxygen and nutrient supply, with consequent lethal damage to the heart ...