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Now showing items 111-120 of 158
Investigating hypoglycaemic effects and safety of the herbal product – jt2016 in vivo study
(University of the Western Cape, 2021)
Diabetes has since been a global epidemic; an estimated 5.0 million deaths of diabetes in the world have been recorded; one in 11 adults have diabetes (415 million); and by 2040, one adult in 10 (642 million) will have ...
The role of arylamine N-acetyltransferase 1 (NAT1) in the clinical therapy of tuberculosis
(University of the Western Cape, 2017)
Despite attempts to develop new drugs to reduce the worldwide mortality rate attributable to
tuberculosis (TB), the illness remains a threat. Isoniazid (INH) has been used as a frontline
drug for decades. However, several ...
The effects of selective inhibitors of N-Glycosylation and Endoplasmic Reticulum stress inducers on Neuroblastoma cell proliferation and Apoptosis
(University of the Western Cape, 2017)
Among all childhood cancers diagnosed, neuroblastoma (NB) is the most prevalent during
infancy. In patients younger than 15 years, it accounts for more than 7% of malignancies and
about 15% of all paediatric mortalities. ...
The potential neuroprotective effects of two South African plant extracts in hydrogen peroxide-induced neuronal toxicity
(University of the Western Cape, 2018)
Background: Oxidative stress induced by reactive oxygen species has been strongly associated with many neurodegenerative diseases (NDDs) and many medicinal plant-derived products have been reported to exert potent antioxidant ...
The potential therapeutic role of palm oil on prostate cancer
(University of the Western Cape, 2020)
Prostate cancer is one of the heterogeneous groups of neoplastic diseases originating from the reproductive system of the male naming, the prostate gland. In the west, prostate cancer is the most common cancer affecting ...
Radioprotective effects of rooibos herbal tea on the developing central nervous system of wistar rats
(University of the Western Cape, 2018)
Background: Early postnatal radiation exposure from environmental, diagnostic or therapeutic
sources is potentially deleterious to the developing nervous system resulting in oxidative stress,
structural damage, altered ...
The Generation of Antibodies against Human Coronavirus NL63 (HCoV-NL63) Nucleocapsid Protein
(University of the Western Cape, 2017)
Coronaviruses (CoVs) are enveloped viruses composed of single-stranded, positive sense
RNA viruses with the largest viral genomes among RNA viruses (27-33 kb). In 2004,
human coronavirus NL63 (HCoV-NL63) was discovered by ...
The effect of rooibos and green tea flavnoids on the physiology of TM3 Leydig cells
(University of the Western Cape, 2018)
Camellia sinensis (C.sinesis) and Aspalathus linearis (A.linearis) are popular beverages consumed in many countries. Consumption of these plants may protect against cardiovascular disease, neurodegenerative disease, various ...
Investigating factors that influence the breeding success of the endangered African penguin (Spheniscus demersus) at a mainland and island colony in the Western Cape, South Africa
(University of Western Cape, 2022)
Since the 1950s the global seabird population have declined by 70% and today some penguin species are amongst the most threatened seabirds in the world. The African penguin (Spheniscus demersus) population experienced a ...
Tyrosol production of Candida species by plant extracts used for skin treatment remedies
(University of the Western Cape, 2022)
The fungal genus Candida is a collection of approximately 150 asporogenous yeast species which are able to cause life-threatening diseases when the normal host defences have been compromised. The most commonly isolated ...