Browsing by Author "Bajic, Vladimir"
Now showing items 1-17 of 17
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A bioinfonnatics approach to the study of the transcriptional regulation of AMPA Glutamate receptors (GRIAs) and genes whose expression are co-regulated with GRIAs
Ghong, Allen K.S. (University of the Western Cape, 2009)It was postulated that each gene has three main sets of transcriptional elements: one which is gene-specific, one which is family-specific, and a third which is tissue-specific. The starting hypothesis for this project had ... -
A bioinformatics approach to the study of the transcriptional regulation of AMPA glutamate receptors (GRIAs) and genes whose expression are co-regulated with GRIAs
Chong, Allen K.S. (2009)It was postulated that each gene has three main sets of transcriptional elements: one which is gene-specific, one which is family-specific, and a third which is tissue-specific.The starting hypothesis for this project had ... -
Computational analyses on transcriptional regulation in mammals
Schmeier, Sebastian (University of the Western Cape, 2009)The genomes of various organisms have been sequenced and their transcriptome elucidated. With the information about genes and gene products readily available it has become of the utmost importance to decipher the underlying ... -
Computational verification of published human mutations
Kamanu, Frederick Kinyua (University of the Western Cape, 2008)The completion of the Human Genome Project, a remarkable feat by any measure, has provided over three billion bases of reference nucleotides for comparative studies. The next, and perhaps more challenging step is to analyse ... -
Concept Based Knowledge Discovery from Biomedical Literature
Radovanovic, Aleksandar. (University of the Western Cape, 2009)This thesis describes and introduces novel methods for knowledge discovery and presents a software system that is able to extract information from biomedical literature, review interesting connections between various ... -
Concept Based Knowledge Discovery From Biomedical Literature
Radovanovic, Aleksandar (University of the Western Cape, 2009)Advancement in biomedical research and continuous growth of scientific literature available in electronic form, calls for innovative methods and tools for information management, knowledge discovery, and data integration. ... -
Development of a hepatitis C virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
Samuel, Kojo Kwofie (2011)To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ... -
Development of a Hepatitis C Virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
Kojo, Kwofie Samuel (University of the Western Cape, 2011)To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ... -
The development of a single nucleotide polymorphism database for forensic identification of specified physical traits
Naidu, Alecia Geraldine (University of the Western Cape, 2009)Many Single Nucleotide Polymorphisms (SNPs) found in coding or regulatory regions within the human genome lead to phenotypic differences that make prediction of physical appearance, based on genetic analysis, potentially ... -
Digital watermarking methods for data security and authentication
Hallot, Mary Lynne (2008)Cryptology is the study of systems that typically originate from a consideration of the ideal circumstances under which secure information exchange is to take place. It involves the study of cryptographic and other processes ... -
Genome-wide identification and comprehensive analysis of transcriptionsl desert regions
Schaefer, UIf (University of the Western Cape, 2009)The initiation of transcription in mammalian genomes predominatly occurs at 5' promoter regions, however increasingly initiation events have been observed within introns, coding exons and 3' UTRs. Nevertheless there ... -
Identification of bacterial pathogenic gene classes subject to diversifying selection
Panji, Sumir (University of the Western Cape, 2009)Availability of genome sequences for numerous bacterial species comprising of different bacterial strains allows elucidation of species and strain specific adaptations that facilitate their survival in widely fluctuating ... -
Incidence and regulatory implications of single Nucleotide polymorphisms among established ovarian cancer genes
Ramdayal, Kavisha (University of the Western Cape, 2009)OVARIAN cancer research focuses on answering important questions related to the disease, determining whether new approaches are feasible to contribute towards improving current treatments or discovering new ones. This study ... -
A knowledgebase of stress reponsive gene regulatory elements in arabidopsis Thaliana
Adam, Muhammed Saleem (University of the Western Cape, 2011)Stress responsive genes play a key role in shaping the manner in which plants process and respond to environmental stress. Their gene products are linked to DNA transcription and its consequent translation into a response ... -
miRNAMatcher: High throughput miRNA discovery using regular expressions obtained via a genetic algorithm
Duvenage, Eugene (University of the Western Cape, 2008)In summary there currently exist techniques to discover miRNA however both require many calculations to be performed during the identification limiting their use at a genomic level. Machine learning techniques are currently ... -
Transcription regulation and candidate diagnostic markers of esophageal cancer
Essack, Magbubah (University of the Western Cape, 2009)Esophageal cancer (EC) ranks among the ten most frequent cancers worldwide. Mortality rates associated with EC are very similar to the incidence rates due to the relatively late stage of diagnosis and the poor efficacy of ... -
Transcriptional regulatory networks in the mouse hippocampus
MacPherson, Cameron Ross (University of the Western Cape, 2007)Neurological diseases are socially disabling and often mortal. To efficiently combat these diseases, a deep understanding of involved cellular processes, gene functions and anatomy is required. However, differential ...