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A microbiological and molecular study of campylobacter and related species isolated from ostriches (Struthio camelus)
(University of the Western Cape, 2014)
Campylobacter and related Epsilonproteobacteria (Arcobacter and Helicobacter) are currently viewed as emerging pathogens and are able to cause gastroenteritis, bacteraemia, the Guillain-Barré syndrome, reactive arthritis ...
Investigating the functional interaction of transcription regulator CarD of Mycobacterium tuberculosis with Ribonucleic Acid Polymerase
(University of the Western Cape, 2014)
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb). TB mainly affects lungs of patients but other parts of the body can also be affected. It kills approximately 2 million people annually. ...
Identification and characterization of microorganisms associated with marine macroalgae Splachnidium rugosum
(University of the Western Cape, 2014)
Marine macroalgae are known to carry diverse bacterial communities which interact with their hosts in both harmful and beneficial ways. Algae hosts provide the bacteria with a rich source of carbon in the form of carbohydrate ...
Cloning and characterization of three compost metagenome-derived α‑L‑Arabinofuranosidases with differing thermal stabilities
(University of the Western Cape, 2014)
Second generation biofuels production requires a suite of lignocellulolytic enzymes, acting synergistically to liberate the fermentable monosaccharides contained within agricultural waste materials. The use of thermostable ...
Structural analysis of induced mutagenesis A’ protein from mycobacterium tuberculosis and of a thermophillic GH9 cellulase
(University of the Western Cape, 2014)
The three-dimensional structures of proteins are important in understanding their function and interaction with ligands and other proteins. In this work, the structures of two proteins, ImuA’ from mycobacterium tuberculosis ...
Identification of biomarkers associated with cervical cancer: a combined in silico and molecular approach
(University of the Western Cape, 2014)
Cervical cancer is the leading cause of cancer mortality among black women in South Africa. It is estimated that this disease kills approximately 8 women in South Africa every day. Cervical cancer is caused by the human ...
Development of a reporter system for the analysis of xylophilus ampelinus type III secreted effectors
(University of the Western Cape, 2014)
Xylophilus ampelinus, the causal agent of bacterial blight and canker of grapevines, has long been a threat to the table grape industry in the Western Cape, leading to severe economic losses due to the reduced productivity ...
Identification of endophytic bacterial communities associated with South African crops: sorghum bicolor (L. Moench), pennisetum glaucum and arachis villosulicarpa
(University of the Western Cape, 2014)
In this study, the diversity of endophytic bacteria associated with food crops, sorghum (Sorghum bicolor L. Moench), pearl millet (Pennisetum glaucum L.) and groundnut (Arachis villosulicarpa) is investigated using ...
Seasonal dynamics of edaphic bacterial communities in the hyper-arid Namib desert
(University of the Western Cape, 2014)
The aim of this study is to investigate the edaphic bacterial community dynamics over short (57 days) and long-term (1 year) sampling intervals using an extensive sampling strategy in combination with community fingerprinting ...
Investigation of protein-metal ion and protein-protein interactions using mass spectrometry and nuclear magnetic spectroscopy
(University of Western Cape, 2014)
Protein-protein interaction networks provide a global picture of cellular function and
biological processes. Some proteins act as hub proteins, highly connected to others, whereas some others have few interactions. The ...