Polymer Coating of an Optimized Nano Lipid Carrier System of Harpagophytum Procumbens Extract for Oral Delivery
Almajdoub, Somaya Saleh
MetadataShow full item record
Harpagophytum procumbens is a traditional medicinal plant widely used in South African traditional healthcare to treat a range of ailments like degenerative rheumatoid arthritis, osteoarthritis, tendonitis, kidney inflammation, heart disease, dyspepsia and loss of appetite. Analgesic and anti-inflammatory effects of Harpagophytum procumbens has been reported to decrease due to stomach acidity. In addition, dried plant extract is water soluble and has poor lipid solubility severely limiting its ability to pass across lipid-rich biological membranes. To overcome this, plant extract was incorporated into a nano lipid alginate coated bead. Harpagophytum procumbens freeze dried aqueous extract was prepared and the active principle harpagoside was identified by mass spectrometry (MS). A simple, linear, accurate and precise UHPLC method was developed for quantitative determination of the bioactive harpagoside. Harpagophytum procumbens was encapsulated in lipid vesicles (liposomes and phytosomes) by using a dry film hydration technique and characterized for particle size, polydispersity index and encapsulation efficiency.