dc.contributor.advisor | Pugh, David J.R. | |
dc.contributor.author | Mulaudzi, Takalani | |
dc.contributor.other | Magister Scientiae - MSc | |
dc.contributor.other | Faculty of Science | |
dc.date.accessioned | 2014-02-10T12:26:45Z | |
dc.date.available | 2007/12/07 10:13 | |
dc.date.available | 2007/12/07 | |
dc.date.available | 2014-02-10T12:26:45Z | |
dc.date.issued | 2007 | |
dc.identifier.uri | http://hdl.handle.net/11394/2833 | |
dc.description | Magister Scientiae - MSc | |
dc.description.abstract | Retinoblastoma binding prot
ein 6 (RBBP6) is a 250 kDa human splicing-associated
protein that is also known to
interact with tumour suppresso
r proteins p53 and pRb and to
mediate ubiquitination of p53 via its intera
ction with Hdm2. RBBP6 is highly up
regulated in oesophageal cancer, and has been shown to be a promising target for immunotherapy against the disease. RBBP6 is also known to play a role in mRNA splicing, cell cycle control and apoptosis. | |
dc.language.iso | en | |
dc.publisher | University of the Western Cape | |
dc.subject | 15N-HSQC | |
dc.subject | 1H-113Cd-HSQC | |
dc.subject | Cadmium ion | |
dc.subject | Coordination | |
dc.subject | Expression | |
dc.subject | RING | |
dc.subject | Spectroscopy | |
dc.subject | Zinc ion | |
dc.title | An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy. | |
dc.type | Thesis | |
dc.rights.holder | University of the Western Cape | |
dc.description.country | South Africa | |