Browsing Department of Biotechnology by Title
Now showing items 343-360 of 360
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Targeted delivery of embelin to cancer cells
(University of the Western Cape, 2013)Apoptosis or programmed cell death is vital to the development of organisms as they maintain the balance between cell death and cell growth. Failure to activate apoptosis has been implicated in carcinogenesis and often ... -
Targeted delivery of GFP loaded polymeric nanoparticles to CD4 expressing cells using a CD4 specific aptamer
(University of the Western Cape, 2020)Human Immunodeficiency Virus (HIV), which is the cause of Acquired Immunodefiency Syndrome (AIDS) is a major global public health issue affecting over 37 million people worldwide and is responsible for claiming over 32 ... -
The effect of exogenous DIM on Brassica napus and its role in response to heavy metal stress
(University of the Western Cape, 2017)Brassica napus is a plant that is used for human and animal consumption. This plant is also used for phytoremediation due to its relatively higher level of heavy metal tolerance. In South Africa, mining is one of the main ... -
The effects of high temperature stress on the enzymatic antioxidant system in Zea mays
(University of the Western Cape, 2017)High temperature stress is synonymous with the attenuation of plant growth, metabolism and eventually death resulting in major loss of crop productivity worldwide. Part of the metabolic perturbations associated with heat ... -
The inhibition of nitric oxide biosynthesis alters anti-oxidant capacity in soybean
(University of the Western Cape, 2016)Nitric oxide is a signalling gaseous molecule endogenously synthesized from various enzymatic and non-enzymatic sources in plants. It is known to play a crucial role in the regulation of plant physiological processes ... -
The molecular validation of miRNA's as specific biomarkers for early diagnosis of ovarian cancer
(University of the Western Cape, 2017)Ovarian Cancer (OC) is the most common reproductive and the most lethal gynaecological malignant tumour. The majority of Ovarian Cancers, comprising more than 95% of cases, emanate from the surface epithelium of the ovary, ... -
The safety and toxicity of MPA-CdTe quantum dots in legume plants
(University of the Western Cape, 2017)The expansion of nanotechnology, resulting in multitudes of consumer and industrial products, causes concern amongst the scientific community regarding the risks associated with the release of nanomaterials into the ... -
Transcription regulation and candidate diagnostic markers of esophageal cancer
(University of the Western Cape, 2009)Esophageal cancer (EC) ranks among the ten most frequent cancers worldwide. Mortality rates associated with EC are very similar to the incidence rates due to the relatively late stage of diagnosis and the poor efficacy of ... -
A transcriptome analysis of apple (Malus x domestica Borkh.) cv ‘golden delicious’ fruit during fruit growth and development
(2013)The growth and development of apple (Malus x domestica Borkh.) fruit occurs over a period of about 150 days after anthesis to full ripeness. During this period morphological and physiological changes occur defining fruit ... -
Tumour specific targeted in vitro theranostics application of fabricated nanostructures in a multi-drug resistant ovarian carcinoma cell line
(University of the Western Cape, 2013)Ovarian cancer is called the “Silent Killer” as it is often diagnosed in advanced stages of the disease or misdiagnosed which ends with a poor prognostic outcome for the patient. A high rate of disease relapse, a high ... -
Using biochemical and nutrient analysis to understand the role of methylglyoxal signalling in soybean exposed to zirconium
(University of the Western Cape, 2017)Soybean have been listed as a priority commodity crop in South Africa (SA) and provide a good source of protein to the population. Therefore, soybean has been earmarked as an important food security crop and strategies are ... -
Using biochemical and nutrient analysis to understand the role of methylglyoxal signalling in soybean exposed to zirconium
(University of the Western Cape, 2017)Soybean have been listed as a priority commodity crop in South Africa (SA) and provide a good source of protein to the population. Therefore, soybean has been earmarked as an important food security crop and strategies ... -
Using CRISPR/Cas9 to construct consolidated bioprocessing strains from natural isolates of Saccharomyces cerevisiae
(University of the Western Cape, 2022)Saccharomyces cerevisiae has gained much attention as a host for cellulosic bioethanol production using consolidated bioprocessing (CBP) methodologies, due to its high ethanol producing titres, heterologous protein producing ... -
Validation and application of a highly discriminating and rapid 10-locus Y-STR DNA profiling system
(University of the Western Cape, 2019)DNA profiling the male specific region on the Y-chromosome is fundamental to forensic practise. Its recognised as a powerful analytical tool for investigation of sexual assault when the DNA evidence is highly admixed. ... -
Valorisation of brewers’ spent grain: enzymatic hydrolysis in the production of xylooligosaccharides
(University of the Western Cape, 2023)The beverage industry constitutes approximately 26% of all food wastes, making it one of the largest contributors in this waste segment. By utilising waste or by-products from agriculture and food production in manufacturing ... -
Y-STR profiling of four South African populations using the University of the Western Cape 10 locus set
(University of the Western Cape, 2015)In this study the 10 Y-specific loci of the University of the Western Cape (DYS710, DYS518 385a/b, DYS644, DYS612, DYS626, DYS504, DYS447, DYS447, and DYS481) were analysed in 492 individuals from South African population ... -
A yeast 2-hybrid screen to identify and characterize interaction partners of the cancer associated protein retinoblastoma binding protein 6
(2009)Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa protein that is implicated in mRNA processing and ubiquitination functions and has been shown to be highly up-regulated in a number of cancers. In humans and mice,RBBP6 ... -
Zirconium-induced physiological and biochemical responses in two genotypes of Brassica napus L.
(University of the Western Cape, 2015)South Africa is one of two countries responsible for the production of approximately 80% of the world’s Zr. The increase in mining activity has detrimental effects on the environment, especially crop plants, as more ...
