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Development of genotyping systems for pharmacogenomics profiling
(University of the Western Cape, 2016)
Genetic variability in genes encoding drug metabolizing enzymes, transporters and targets are known to be the main factors of inter-individual differences in therapeutic outcome. Genetic factors are estimated to be responsible ...
Genomic diversity and functional analysis of the solute carrier genes within indigenous African and Cape Admixed populations
(University of the Western Cape, 2016)
Solute carrier transporters belonging to the major facilitator family of membrane transporter are increasingly being recognized as a possible mechanism to explain inter-individual variation in drug efficacy and response. ...