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Now showing items 21-30 of 226
Tumour specific targeted in vitro theranostics application of fabricated nanostructures in a multi-drug resistant ovarian carcinoma cell line
(University of the Western Cape, 2013)
Ovarian cancer is called the “Silent Killer” as it is often diagnosed in advanced stages of the disease or misdiagnosed which ends with a poor prognostic outcome for the patient. A high rate of disease relapse, a high ...
Identification of miRNA's as specific biomarkers in prostate cancer diagnostics : a combined in silico and molecular approach
(University of the Western Cape, 2015)
There are over 100 different types of cancer, and each of these cancers are classified by the type of cell that it initially affects. For the purpose of this research we will be focussing on prostate cancer (PC). Prostate ...
The isolation and characterisation of novel natural products from marine bacterial symbionts
(University of the Western Cape, 2015)
Drug-resistant infections are a global health crisis and drastically hinder the treatment options to effectively combat disease. Today, natural products remain an important source of novel drug candidates. Micro-organisms, ...
In silico and molecular validation of identified putative genes and functional analysis of a N K G2D ligand as a breast cancer biomarkers
(University of the Western Cape, 2015)
The current diagnostic, prognostic, predictive and therapeutic monitoring methods
used for breast cancer are limited. Thus, research into more specific, sensitive and
effective strategies is required. Breast cancer is ...
Matrix comparison of isolation conditions for secondary metabolite producing marine sponge associated bacteria
(University of the Western Cape, 2015)
The discovery of novel secondary metabolites has declined significantly in recent years whereas there is a rise in the number of multi-drug resistant pathogens and other types of diseases. The decline in natural product ...
Identification of microRNAs as a class of biomarkers for the early diagnosis of prostate cancer : an in silico and molecular approach
(University of the Western Cape, 2015)
Prostate cancer (PCa) is the second most common form of cancer in men around
the world. In many parts of Africa, data on prostate cancer is sparse. This is
attributed to poor access to testing and diagnostics. The ...
Identification of potential biomarkers in lung cancer as possible diagnostic agents using bioinformatics and molecular approaches
(University of the Western Cape, 2015)
Lung cancer remains the leading cause of cancer deaths worldwide, with the majority of cases attributed to non-small cell lung carcinomas. At the time of diagnosis, a large percentage of patients present with advanced stage ...
Screening for fluorescent and chromoproteins from South African sea anemones
(University of the Western Cape, 2012)
Sea anemones (Order Actinaria) are a diverse order from the Class Anthozoa. They are found in all marine habitats at all depths and their symbiotic relationships play an important role in energy transfers especially in the ...
Bioprospecting for bioactive polysaccharides from marine algae endemic to South Africa
(University of the Western Cape, 2016)
Fucoidan is a marine-derived sulphated polysaccharide with bioactive properties ideal for the food, chemical and pharmaceutical industries. The polysaccharide consists largely of L-fucose, has a highly heterogeneous structure ...
Proteome signature of breast cancer cells treated with fucoidan
(University of the Western Cape, 2016)
Breast cancer is responsible for a large portion of cancer-related deaths. Worldwide, incidence is increasing. Routinely-used treatments for breast cancer are invasive and are associated with a range of side-effects which ...