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The structure of the nitrilase from Rhodococcus Rhodochrous J1: homology modeling and three-dimensional reconstruction
(University of the Western Cape, 2006)
The nitrilases are an important class of industrial enzymes that are found in all phyla. These enzymes are expressed widely in prokaryotes and eukaryotes. Nitrilases convert nitriles to corresponding acids and ammonia. ...
Screening extracts of indigenous South African plants for the presence of anti-cancer compounds
(University of the Western Cape, 2006)
Early man dabbled with the use of plant extracts to cure ailments. This practice has been passed down from generation to generation and today more than 50% of the world'sdrugs are natural products or derivatives thereof. ...
Metagenomic approaches to gene discovery
(University of the Western Cape, 2006)
The classical approach to gene discovery has been to culture micro-organisms demonstrating a specific enzyme activity and then to recover the gene of interest through shotgun cloning. The realization that these standard ...
Identification and characterisation of a novel gene, DWNN, isolated from promoter-trapped Chinese hamster ovary cells
(University of the Western Cape, 2005)
The process of cytotoxic T lymphocyte (CTL) killing involves the recognition and destruction of foreign antigens by cytotoxic T cells and is of crucial importance to the defence of the organism against viral infections. ...
Phylogenetic diversity of nifH genes in Marion Island soil
(University of the Western Cape, 2006)
The microbial life of sub-Antarctic islands plays a key role in the islands ecosystem, with microbial activities providing the majority of nutrients available for primary production. Knowledge of microbial diversity is ...
Investigation of South African estuarine microbial species and genome diversity
(University of the Western Cape, 2006)
A study of the microbial diversity in sediments of the Great Berg River estuary is carried out using modern molecular phylogenetic methods. The aim of this study was to determine the effect of (pollution by) the effluents ...
Iterative helical real-space reconstruction of histone octamer tubular crystals and implications for the 30 nm chromatin fiber
(University of the Western Cape, 2006)
This thesis investigated the helical structure of core histone octamers to discover interacting surfaces and their relevance to the compaction of nucleosome arrays into the chromating fiber.
Microbial diversity of Antarctic Dry Valley mineral soil
(University of the Western Cape, 2004)
Antarctica provides some of the most extreme environments on earth. Low temperatures, low water availability and nutrient deficiency are contributing factors to the limited colonisation of Antarctic biotopes, particularly ...
The prevalence and survival of Campylobacter, Salmonella and Listeria species in poultry processing plant
(University of the Western Cape, 2004)
The organisms in this study were chosen due to their associations with foods and their potential as food borne pathogens. Food borne diseases are an import public health problem in most countries. Bacteria of the genera ...
Microbiology of fly ash-acid mine drainage co-disposal processes
(University of the Western Cape, 2005)
The waste products acid mine drainage formed during coal mining and fly ash from coal burning power generation, pose substantial environmental and economic problems for South Africa. Eskom has developed a remediation system ...