Browsing Philosophiae Doctor - PhD (Biotechnology) by Author "Benjeddou, Mongi"
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Genomic diversity and functional analysis of the solute carrier genes within indigenous African and Cape Admixed populations
Pearce, Brendon Clive (University of the Western Cape, 2016)Solute carrier transporters belonging to the major facilitator family of membrane transporter are increasingly being recognized as a possible mechanism to explain inter-individual variation in drug efficacy and response. ... -
Identification of sub-clinical biomarkers that predict the risk of developing diabetic cardiomyopathy
Nxele, Xolisa (University of the Western Cape, 2022)Cardiovascular disease (CVD) is the leading cause of death of people with obesity and type 2 diabetes (T2DM). According to a statistical report from the World Health Organization (WHO), approximately 17.9 million people ... -
Inter-individual genetic variation and the development of hypertension in a Xhosa African population of Eastern Cape, South Africa
Mabhida, Sihle Ephraim (University of the Western Cape, 2022)Cardiovascular diseases (CVD) are the leading cause of death globally, accounting for 18.6 million deaths. Hypertension (HTN) drives the global burden of CVD and is a leading cause of cardiovascular-related mortality with ... -
Molecular detection and genetic manipulation of the Black Queen Cell Virus
Benjeddou, Mongi (University of the Western Cape, 2002)The South African isolate of the Black Queen-Cell Virus (BQCV), a honeybee virus, was previously found to have an 8550 nucleotide genome excluding the poly(A) tail. Its genome contained two ORFs, a 5'-proximal ORF encoding ... -
Pharmacogenomics of solute carrier transporter genes in the Xhosa population
Jacobs, Clifford Winston (University of the Western Cape, 2014)Solute carrier transporters belonging to the major facilitator family of membrane transporter are increasingly being recognized as a possible mechanism to explain inter-individual variation in drug efficacy and response. ...