Browsing Magister Pharmaceuticae - MPharm by Title
Now showing items 30-49 of 140
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Design and evaluation of fast dispersible tablets of lamivudine using selected natural superdisintegrants
(University of the Western Cape, 2018)Fast dispersible tablets (FDTs) are solid single-unit dosage forms that are placed in the mouth and allowed to disperse or dissolve in the saliva without the need of water. The basic approach to formulating FDTs consists ... -
Design of a thermoresponsive hydrogel for enhanced intratumoral permeation of a chemotherapeutic agent in oral squamous cell carcinoma
(University of the Western Cape, 2023)Introduction: Oral squamous cell carcinoma is the most common and aggressive cancer occurring in the oral cavity. Intravenous chemotherapy remains a pivotal part of treatment for the disease; however, these drugs cause ... -
Design, implementation and evaluation of a model for Service-learning in Pharmacy (SLIP) at a tertiary hospital
(University of the Western Cape, 2009)In recent years the focus of pharmacy practice has changed from being primarily 'drug-centred to' one which is 'patient-centred' (El-Awady et al., 2006, p. l ). Developments in pharmacy curricula worldwide are reflecting ... -
Design, implementation and evaluation of a model for service-learning in pharmacy (slip) at a Tertiary hospital
(2009)Background In recent years the focus of pharmacy practice has changed from being primarily ‘drugcentred to’ one which is ‘patient-centred’ (El-Awady et al., 2006, p.1). Developments in pharmacy curricula worldwide are ... -
The design, preparation and evaluation of Artemisia Afra and placebos in tea bag dosage form suitable for use in clinical trials
(University of the Western Cape, 2006)Artemisia Afra, a popular South African traditional herbal medicine is commonly administered as a tea infusion of the leaves. However, clinical trials proving it safety and efficacy are lacking mainly due to the absence ... -
Design, Synthesis and Evaluation of Indole Derivatives as Multifunctional Agents against Alzheimer's disease.
(University of the Western Cape, 2017)Alzheimer's disease (AD) is an age related neurodegenerative disorder characterised by progressive memory loss and cognitive impairment. It is one of several neurodegenerative disorders occurring as a result of a process ... -
Determination of kanamycin plasma concentrations using LC/MS and pharmacokinetics of kanamycin in patients with multidrug-resistant tuberculosis and in patients with multidrug-resistant tuberculosis co-infected with HIV
(University of the Western Cape, 2012)The aim of the study was to determine firstly, kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC/MS); secondly, to investigate the PK parameters of kanamycin in patients infected ... -
Determination of plasma concentrations using Lc/ms and pharmacokinetics of ofloxacin in Patients with multi-drug resistant tuberculosis and In patients with multi-drug resistant tuberculosis co- Infected with hiv
(University of the Western Cape, 2009)Many studies have investigated the pharmacokinetics of anti-tuberculosis drugs in patients infected with tuberculosis. However, little is known about the pharmacokinetics of the drugs that are used in the treatment of ... -
Determination of plasma concentrations using LC/MS and pharmacokinetics of ofloxacin in patients with multi-drug resistant tuberculosis and in patients with multi-drug resistant tuberculosis coinfected with hiv
(2009)Many studies have investigated the pharmacokinetics of anti-tuberculosis drugs in patients infected with tuberculosis. However, little is known about the pharmacokinetics of the drugs that are used in the treatment of ... -
Determination of pyrazinamide plasma concentrations using lc-ms and pharmacokinetics of pyrazinamide in patients with multidrug-resistant tuberculosis and in patients co-infected with multidrug-resistant tuberculosis and HIV
(2013)Tuberculosis and HIV are arguably South Africa’s largest and most important health issues. With drug-resistant strains of tuberculosis on the increase and little research on new drugs, there is an urgent need for research ... -
The development and evaluation of the Objective Structured Dispensing Examination (OSDE) for use in an undergraduate pharmacy training programme
(University of the Western Cape, 2004) -
Development of a model to predict the cost of management of diabetes mellitus and its complications at Groote Schuur Hospital
(University of the Western Cape, 2012)Diabetes mellitus places a substantial financial burden on the funder for treatment of this disease. This burden is compounded by the development of diabetes mellitus related complications. The cost of management of diabetes ... -
Development of a model to predict the cost of treatment of breast cancer with chemotherapy at Groote Schuur hospital
(University of the Western Cape, 2017)In South Africa, breast cancer dominates other forms of cancer affecting women in both prevalence and mortality rates according to the National Cancer Registry. The incidence and cost of breast cancer have been on the rise ... -
Development, implementation and evaluation of a diabetes educational outreach inervention for pharmacists
(University of the Western Cape, 2007)Increasing diabetes prevalence rates, poor involvement of and limited knowledge among health care professionals in disease management, and poor implementation of guidelines are barriers to quality diabetes care. This thesis ... -
Discovery of cytotoxic natural products from South African marine sponges
(University of the Western Cape, 2018)Cancer is a major health problem worldwide and killing millions of people each year. The use of natural products as chemotherapeutic agents is well established, however, many of the currently available drugs are associated ... -
Disposal of unused medicines from households in Cape Town
(University of Western Cape, 2019)Evidence indicates that most South African households do not dispose of unused medicines in the manner prescribed by the medicine’s regulatory authority. This trend is not unique to South Africa, but several developing ... -
Dissolution and antiviral activity of a novel nevirapine formulation
(University of the Western Cape, 2014)The author’s objective was to follow the product life-cycle process of a novel antiretroviral, nevirapine formulation in South Africa, to generate and compile data to pursue market registration. Five supramolecular ... -
Efavirenz pre-formulation study : selection of a cyclodextrin inclusion complex or co-crystal complex for tabletting
(University of the Western Cape, 2015)Efavirenz is a non-nucleoside reverse transcriptase inhibitor used as an anti-retroviral for the treatment of human immunodeficiency virus (HIV) type I. It is classified as a class IΙ drug under the Biopharmaceutical ... -
The effect of co-crystallization and polymorphism on the physicochemical properties of amoxicillin tri-hydrate
(University of the Western Cape, 2013)Many active pharmaceutical ingredients (APIs) have poor physicochemical properties such as solubility, dissolution and chemical stability. Several strategies are used to enhance and improve these properties of the API. ... -
Effect of inhaled cationic poly-peptides on respiratory mechanics in the isolated perfused rat lung
(University of the Western Cape, 1998)The inhalation route is increasingly being considered as a viable option to deliver protein drugs into the body, but there has been few studies dealing with the safety of this strategy. The results of in vitro studies have ...
