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Computational strategies to identify, prioritize and design potential antimalarial agents from natural products
(University of the Western Cape, 2015)
Introduction: There is an exigent need to develop novel antimalarial drugs in view of the mounting disease burden and emergent resistance to the presently used drugs against the malarial parasites. A large amount of natural ...
Concept Based Knowledge Discovery from Biomedical Literature
(University of the Western Cape, 2009)
This thesis describes and introduces novel methods for knowledge discovery and presents a software system that is able to extract information from biomedical literature, review interesting connections between various ...
Prediction of antimicrobial peptides using hyperparameter optimized support vector machines
(University of the Western Cape, 2011)
Antimicrobial peptides (AMPs) play a key role in the innate immune response. They can be ubiquitously found in a wide range of eukaryotes including mammals, amphibians, insects, plants, and protozoa. In lower organisms, ...
Computational prediction of host-pathogen protein-protein interactions
(University of the Western Cape, 2017)
Supervised machine learning approaches have been applied successfully to the prediction of protein-protein interactions (PPIs) within a single organism, i.e., intra-species predictions. However, because of the absence of ...
Concept Based Knowledge Discovery From Biomedical Literature
(University of the Western Cape, 2009)
Advancement in biomedical research and continuous growth of scientific literature available in electronic form, calls for innovative methods and tools for information management, knowledge discovery, and data integration. ...