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Computational strategies to identify, prioritize and design potential antimalarial agents from natural products
(University of the Western Cape, 2015)
Introduction: There is an exigent need to develop novel antimalarial drugs in view of the mounting disease burden and emergent resistance to the presently used drugs against the malarial parasites. A large amount of natural ...
Computational genomics approaches for kidney diseases in Africa
(University of the Western Cape, 2015)
End stage renal disease (ESRD), a more severe form of kidney disease, is considered to be a complex trait that may involve multiple processes which work together on a background of a significant genetic susceptibility. ...
Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer
(University of the Western Cape, 2015)
Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a ...