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Now showing items 4286-4305 of 8899
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Identification of microRNAs as a class of biomarkers for the early diagnosis of prostate cancer : an in silico and molecular approach
(University of the Western Cape, 2015)Prostate cancer (PCa) is the second most common form of cancer in men around the world. In many parts of Africa, data on prostate cancer is sparse. This is attributed to poor access to testing and diagnostics. The ... -
Identification of miRNA's as specific biomarkers in prostate cancer diagnostics : a combined in silico and molecular approach
(University of the Western Cape, 2015)There are over 100 different types of cancer, and each of these cancers are classified by the type of cell that it initially affects. For the purpose of this research we will be focussing on prostate cancer (PC). Prostate ... -
The identification of novel biomarkers in response to pollutant exposure using proteome profiler arrays
(University of Western Cape, 2020)Nanotechnology is a rapidly expanding field with a multitude of practical uses namely textiles, cosmetics, agriculture, and health sciences. The focus, for the purposes of this thesis, will be on carbon dots. The small ... -
Identification of novel cold-adapted nitrilase superfamily enzymes
(2009)In bacteria, nitrile hydratases and enzymes of nitrilase and signature amidase superfamilies hydrolyse nitriles and amides to their corresponding carboxylic acids releasing ammonia. Bacteria expressing these enzymes are ... -
Identification of novel microRNAs as potential biomarkers for the early diagnosis of ovarian cancer using an in-silico approach
(University of the Western Cape, 2019)Ovarian cancer (OC) is the most fatal gynaecologic malignancy that is generally diagnosed in the advanced stages, resulting in a low survival rate of about 40%. This emphasizes the need to identify a biomarker that can ... -
Identification of novel miRNAs as diagnostic and prognostic biomarkers for prostate cancer using an in silico approach
(University of the Western Cape, 2017)Cancer is known as uncontrollable cell growth which results in the formation of tumours in the areas that are affected by the cancer. There are two types of tumours: benign and malignant. This study focus is on prostate ... -
Identification of novel miRNAs as diagnostic molecules for detection of breast cancer using in silico approaches
(University of the Western cape, 2017)Breast cancer (BC) is the most common cancer in women worldwide, and is the second most common cancer in the world, responsible for more than 500 000 deaths annually. Estimates are that 1 in 8 women will develop BC in their ... -
The identification of novel regulatory elements in the promoters of heat shock response genes
(University of the Western Cape, 2010)The main objective of this study was to investigate promoter sequences of putative HSR genes for the presence of unique regulatory elements and modules that might be involved in the regulation of HSR. In order to achieve ... -
Identification of potential antibiofilm hit compounds from two African natural product database against multi-drug resistant staphylococcus aureus: an in silico study
(University of the Western Cape, 2023)One of the crucial ways by which Staphylococcus aureus develops resistance to antibiotics is biofilm formation, a protective mechanism involving extracellular polymeric substance (EPS) matrix that shields microorganisms ... -
Identification of potential biomarkers in lung cancer as possible diagnostic agents using bioinformatics and molecular approaches
(University of the Western Cape, 2015)Lung cancer remains the leading cause of cancer deaths worldwide, with the majority of cases attributed to non-small cell lung carcinomas. At the time of diagnosis, a large percentage of patients present with advanced stage ... -
The identification of potential groundwater zones in the Kamiesberg region, Northern Cape province, South Africa
(University of the Western Cape, 2003)The aim of the study is to apply remote sensing techniques to identify potential groundwater resources for the Kamiesberg region. This region, with vast water shortages relies solely on groundwater and is characterized by ... -
Identification of quantitative trait loci control l ing the requirement for chilling in vegetative budbreak in apple (malus x domestica borkh.)
(2008)The domesticated apple (Malus x domestica Borkh.) has been distributed into diverse climatic conditions worldwide for commercial production of fruit. Apple trees need exposure to cold temperatures, referred to as chill ... -
identification of Quantitative Tralt Locl Controlling the Requirement for chilling ln Vegetative budbreak in apple (malus x domestica Borkh')
(University of the Western Cape, 2007)The domesticated apple (Malus x domestica Borkh.) has been distributed into diverse climatic conditions worldwide for commercial production of fruit. Apple trees need exposure to cold temperatures, referred to as chill ... -
The identification of regulatory Elements in pseudomonas aeruginosa and p. putida responsive to specific heavy metals.
(University of Western Cape, 1999)Heavy metals constitute a group of about sixty-five elements having a density greater than five (Gadd and Griffiths, 1978). Some metals, for example lead, copper, and nickel are extremely precious and profitable to man ... -
Identification of rhizospheric microorganisms associated with sorghum
(University of the Western Cape, 2012)Approximately 50% of sorghum (Sorghum bicolour (L.) Moench) produced globally is used as human food, with 95% of its total consumption occurring in Africa. Unfortunately, sorghum crops are prone to pathogenic attack, notably ... -
Identification of ruantitative trait loci controlling the requirement for chilling in vegetative budbreak in apple (Malus x domestica Borkh.)
(2008)The domesticated apple (Malus x domestica Borkh.) has been distributed into diverse climatic conditions worldwide for commercial production of fruit. Apple trees need exposure to cold temperatures, referred to as chill ... -
Identification of sub-clinical biomarkers that predict the risk of developing diabetic cardiomyopathy
(University of the Western Cape, 2022)Cardiovascular disease (CVD) is the leading cause of death of people with obesity and type 2 diabetes (T2DM). According to a statistical report from the World Health Organization (WHO), approximately 17.9 million people ... -
Identification, resolution and monitoring of barriers to the availability of essential drugs at primary health care facilities in Lejweleputswa district, Free State Province
(University of the Western Cape, 2005)This study aimed to identify barriers to the availability of essential drugs at health facilities, to identify implementable solutions to those barriers, to develop a monitoring system for tracking implementation of solutions ... -
Identification, separation and quantification of persistent organic pollutants using capillary electrophoresis
(University of the Western Cape, 2022)Water quality deterioration and scarcity can be attributed to natural causes and anthropogenic activities which include climate change and an incessant industrialisation, yet with lack of functional and reliable wastewater ... -
Identifying academic reading strategies in a multilingual context
(University of the Western Cape, 2014)In this thesis I explore the complexity of FL (Foreign Language) reading through qualitatively and quantitatively analysing the forms, ways, and mechanisms applied by adult readers at tertiary university education level ...