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Now showing items 8027-8046 of 8899
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Synthesis and evaluation of fluorescently linked polycyclic cage derivatives for application in neurodegenerative disorders
(University of the Western Cape, 2020)Neurodegenerative diseases (ND) are chronic and progressive in nature, and characterized by the gradual loss of neurons in various regions of the central nervous system (CNS). ND include Alzheimer's disease (AD), Parkinson's ... -
Synthesis and evaluation of metformin derivatives for anti-diabetes
(University of the Western Cape, 2022)Type 2 diabetes mellitus (T2DM) is a significant public health crisis and is placed amongst the top ten leading causes of death worldwide. Metformin is the first-line drug used to treat T2DM, which is mainly attributed to ... -
Synthesis and evaluation of novel coumarin-donepezil derivatives as dual acting monoamine oxidase B and cholinesterase in Alzheimer's disease
(University of the Western Cape, 2016)Alzheimer's disease is a progressive neurodegenerative disease characterised by low acetylcholine (ACh) levels in the hippocampus and cortex of the brain, causing symptoms like progressive memory loss, decline in language ... -
The synthesis and evaluation of potential anti-Mycobacterium tuberculosis and apoptotic agents
(University of the Western Cape, 2007)Tuberculosis (TB) and Cancer are among the most devastating and therapeutically challenging diseases that need to be addressed in South Africa today. The development of muti-drug resistance in TB causing bacteria, Mycobacterium ... -
Synthesis and Luminescence of Zinc Oxide Nanorods-Blended Thiopheno-Organosilicon Polymers
(University of the Western Cape, 2017)The increasing cost of fossil fuel energy production and its implication in environmental pollution and climate change created high demand for alternative and renewable sources of energy. This has led to great interest ... -
Synthesis and Physicochemical Characterisation of Poly (?-caprolactone) Nanoparticles for Delivery of Propranolol
(University of the Western Cape, 2017)Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality in both developed and developing countries; and account for around 30% of all deaths worldwide. Reports indicate that nanoparticle (NP) based drug ... -
Synthesis and Physicochemical Characterisation of Poly (?-caprolactone) Nanoparticles for Delivery of Propranolol
(University of the Western Cape, 2017)Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality in both developed and developing countries; and account for around 30% of all deaths worldwide. Reports indicate that nanoparticle (NP) based drug ... -
Synthesis and properties of nanoparticulate titanium dioxide compounds
(University of the Western Cape, 2009)An electrolytic cell was designed and constructed for the preparation of TiO2 nanotubes. Conditions of anodic oxidation were established to reproducibly prepare TiO2 nanotubes of average length 35-50 μm vertically orientated ... -
The synthesis of 3-allyl-4-ethyl-2- (1'-hydroxyethyl)-1-methoxynaphthalene and its behaviour towards base- and palladium-promoted cyclisation under aerobic and anaerobic conditions
(University of the Western Cape, 2005)Over the years, Giles and co-workers have established that, upon treatment with potassium tert-butoxide, tetra-substituted naphthalenes undergo cyclisations to afford naphthopyrans. It was suggested that these base-induced ... -
The synthesis of analogues of the Anti-TB (agent: Diospyrin)
(University of the Western Cape, 2005)Diospyrin, a bisnaphthyl quinone molecule with proven anti-TB activity can be retrosynthetically formulated into two halves. In this work, the analogue chosen to be synthesized was similarly retrosynthesized into two halves. ... -
The Synthesis of Biaxial Naphthoquinones and an Initial Investigation regarding their Potential as anti- Mycobacterium tuberculosis and Apoptotic Agents
(University of the Western Cape, 2009)Tuberculosis and cancer are amongst the most devastating diseases affecting the world today, especially Africa and other less developed countries. Both diseases have the ability to develop resistance against drugs being ... -
Synthesis of bimetallic immiscible alloy nanoparticles through green and gamma radiolysis approaches for environmental remediation applications
(University of the Western Cape, 2022)The synthesis of bimetallic immiscible alloy nanoparticles (NPs) using versatile routes, is a major concern since physio-chemical methods are not environmentally benign. Breaking down the immiscibility would generate NPs ... -
Synthesis of bimetallic immiscible alloy nanoparticles through green and gamma radiolysis approaches for environmental remediation applications
(University of the Western Cape, 2022)The synthesis of bimetallic immiscible alloy nanoparticles (NPs) using versatile routes, is a major concern since physio-chemical methods are not environmentally benign. Breaking down the immiscibility would generate NPs ... -
Synthesis of binary and ternary Pd-based Nanocatalysts for alcohol oxidation in alkaline media for fuel cell application
(University of the Western Cape, 2020)This study explores the use of UV-assisted reduction method to synthesise the catalysts, aiming at reducing synthesis time. The Pd and Au catalyst loading is kept at 5 wt% in order to reduce the cost associated with high ... -
Synthesis of DMSO based silver nanoparticles for application in wound healing
(University of Western Cape, 2021)Silver nanoparticles (AgNPs) apart from being chemically significant, have shown a lot of health benefits, the most studied being their anti-bacterial and anti-inflammatory properties. These biological properties can be ... -
Synthesis of metal modified Mesoporous Zeolites catalysts: application in conversion of Olefins to Valuable liquid products
(University of the Western Cape, 2016)The effects of temperature, synthesis duration and silica source were studied to obtain suitable conditions for our laboratory experiment concerned with the synthesis of MCM-41 catalyst. The transformation of 1-hexene was ... -
The synthesis of methoxy-2-hydroxy-1,4- naphthoquinones and their reaction with aliphatic aldehydes under basic conditions.
(University of the Western Cape, 2003)Although literature reports on the synthesis of variously substituted 2-hydroxy-1 ,4- naphthoquinones appeared to be reasonable; in our hands difficulty was experienced in duplicating much of the work. In order to address ... -
Synthesis of multi-metallic catalysts for fuel cell applications
(University of the Western Cape, 2008)The direct methanol fuel cell or DMFC is emerging as a promising alternative energy source for many applications. Developed and developing countries, through research, are fast seeking a cheap and stable supply of energy ... -
Synthesis of new biguanide derivatives as potential antidiabetic drugs
(University of the Western Cape, 2022)The main purpose of this study was to synthesize biguanide compounds with potential as antidiabetic drugs. All biguanide compounds possess antidiabetic properties by decreasing the blood glucose level. Hence, we embarked ... -
Synthesis of One-Dimensional TiO2 Nanotube Arrays by Potentiostatic Anodisation
(University of the Western Cape, 2017)TiO2 nanomaterials, in particular nanotubes, are some of the most studied materials, as they are considerably important in technological and biological applications due to their unique electronic properties and biocompatibility. ...