Browsing by Author "Samsodien, Halima"
Now showing items 1-14 of 14
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Biosimilar’s Growth in Pharmerging Markets: An Analysis of the Regulatory Environments
Batel, Ryma (University of the Western Cape, 2020)The introduction of biosimilars to health care markets across the globe has had some success in increasing competition and improving the cost of healthcare. While savings are important for driving the biosimilar uptake, ... -
Content levels, in vitro dissolution and predicted bioavailability of flavonoids from Sutherlandia frutescens leaf powder and aqueous extracts
Mbamalu, Oluchi Nneka (University of the Western Cape, 2015)Various formulations of the popular South African medicinal plant, Sutherlandia frutescens,are commercially available, with no documented specifications for quality assessment. With plans already underway for a clinical ... -
A crystal engineering study of selected sulfa drugs and trimethoprim
Elbakush, Rasha Elmheidi (University of the Western Cape, 2014)The objective was to prepare new solid phases, i.e. co-crystal forms, of two sulfa antibiotic drugs (sulfamethoxazole and sulfasalazine) with trimethoprim and fourteen potential co-formers with GRAS status. Trimethoprim ... -
Design and evaluation of fast dispersible tablets of lamivudine using selected natural superdisintegrants
Noutchang, Yves Roland Tchakounte (University of the Western Cape, 2018)Fast dispersible tablets (FDTs) are solid single-unit dosage forms that are placed in the mouth and allowed to disperse or dissolve in the saliva without the need of water. The basic approach to formulating FDTs consists ... -
Development of rifampicin loaded in surface-modified 4.0 G PAMAM dendrimer as a novel antituberculosis pulmonary drug delivery system
Ahmed, Rami M. Y. (University of the Western Cape, 2020)Introduction: Tuberculosis (TB) is a serious bacterial infections caused by the Mycobacterium Tuberculosis (MTB) organism affecting mainly the lungs. Occasionally, MTB bacilli may be transported out of the pulmonary region ... -
Dissolution and antiviral activity of a novel nevirapine formulation
Geldenhuys, Brandon Lindsay (University of the Western Cape, 2014)The author’s objective was to follow the product life-cycle process of a novel antiretroviral, nevirapine formulation in South Africa, to generate and compile data to pursue market registration. Five supramolecular ... -
Efavirenz pre-formulation study : selection of a cyclodextrin inclusion complex or co-crystal complex for tabletting
Rafieda, Ali Mohamed Omar (University of the Western Cape, 2015)Efavirenz is a non-nucleoside reverse transcriptase inhibitor used as an anti-retroviral for the treatment of human immunodeficiency virus (HIV) type I. It is classified as a class IΙ drug under the Biopharmaceutical ... -
The effect of co-crystallization and polymorphism on the physicochemical properties of amoxicillin tri-hydrate
Jaaida, Nesren Al-Hadi (University of the Western Cape, 2013)Many active pharmaceutical ingredients (APIs) have poor physicochemical properties such as solubility, dissolution and chemical stability. Several strategies are used to enhance and improve these properties of the API. ... -
The formulation and characterisation of corticosteroid loaded Ethosomes for topical delivery
Martin, Björn Franklin (University of the Western Cape, 2020)Background/Introduction: Atopic dermatitis (AD) is one of the most prevalent diseases worldwide. It is a rapidly growing field of study with several research avenues to explore its pathophysiology and to find innovative ... -
Formulation and evaluation of polymeric micelles for improved oral delivery of tenofovir disoproxil fumarate and zidovudine using poly-lactic-co-glycolic acid nanoparticles
Tenghe, Lovette Asobo (University of the Western Cape, 2018)Background: Tenofovir disoproxil fumarate (TDF) and Zidovudine (AZT) are both nucleotide and nucleoside analogue reverse transcriptase inhibitors (NtRTIs and NRTIs), respectively. They are used for the management and ... -
Formulation and evaluation of zidovudine cyclodextrin inclusion complex to enhance acid lability and palatability
Al-Derbali, Meftah Abdulhafied (University of the Western Cape, 2016)Background: Zidovudine (AZT) is a very useful drug for the management of Human Immunodeficiency Virus (HIV) infection. Its optimal use is limited by its bitter taste, sparing solubility (20.1 mg/ml) and acid lability. ... -
Formulation of a nevirapine co-crystal as a liquid dosage form
Injety, Sahana (University of the Western Cape, 2016)Co-crystals are a solid phase phenomena that could enhance the physicochemical properties of an active pharmaceutical ingredient. A co-crystal has never been incorporated into a liquid dosage form with the assurance of ... -
Selected antiretroviral and anti-tuberculosis drug combinations by non-covalent bonding
Ngilirabanga, Jean Baptiste (University of Western Cape, 2021)Treatment of the human immunodeficiency virus (HIV) and tuberculosis (TB) infections have become very complicated due to the advent of drug resistance. Drug combinations offer an alternative approach to reducing the emergence ... -
A supramolecular derivatised study of BIS(Adamantan-1- Aminium) carbonate
Ngilirabanga, Jean Baptiste (University of the Western Cape, 2014)In this study, new solid supramolecular derivatised forms of bis(adamantine-1-aminium) carbonate (ADTCO3) were prepared. ADTCO3 is a derivative of amantadine used for Parkinson’s disease and has antiviral properties against ...