Browsing South African National Bioinformatics Institute (SANBI) by Title
Now showing items 14-33 of 84
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A computational characterisation of the relationship between genome structure and disease genes
(University of the Western Cape, 2012)This is a pilot study to investigate the relationship between disease gene status and the structure of the human genome with specific reference to regions of recombination. It compares certain characteristics of a control ... -
Computational characterization of IRE-regulated genes in Glossina morsitans
(University of Western Cape, 2013)Blood feeding is a habit exhibited by many insects. Considering the devastating impact of these insects on human health, it is important to focus research on understanding the biology behind blood-feeding, disease ... -
Computational genomics approaches for kidney diseases in Africa
(University of the Western Cape, 2015)End stage renal disease (ESRD), a more severe form of kidney disease, is considered to be a complex trait that may involve multiple processes which work together on a background of a significant genetic susceptibility. ... -
Computational prediction of host-pathogen protein-protein interactions
(University of the Western Cape, 2017)Supervised machine learning approaches have been applied successfully to the prediction of protein-protein interactions (PPIs) within a single organism, i.e., intra-species predictions. However, because of the absence of ... -
Computational strategies to identify, prioritize and design potential antimalarial agents from natural products
(University of the Western Cape, 2015)Introduction: There is an exigent need to develop novel antimalarial drugs in view of the mounting disease burden and emergent resistance to the presently used drugs against the malarial parasites. A large amount of natural ... -
Computational verification of published human mutations
(University of the Western Cape, 2008)The completion of the Human Genome Project, a remarkable feat by any measure, has provided over three billion bases of reference nucleotides for comparative studies. The next, and perhaps more challenging step is to analyse ... -
Concept Based Knowledge Discovery from Biomedical Literature
(University of the Western Cape, 2009)This thesis describes and introduces novel methods for knowledge discovery and presents a software system that is able to extract information from biomedical literature, review interesting connections between various ... -
Concept Based Knowledge Discovery From Biomedical Literature
(University of the Western Cape, 2009)Advancement in biomedical research and continuous growth of scientific literature available in electronic form, calls for innovative methods and tools for information management, knowledge discovery, and data integration. ... -
Data Science techniques for predicting plant genes involved in secondary metabolites production
(University of the Western Cape, 2018)Plant genome analysis is currently experiencing a boost due to reduced costs associated with the development of next generation sequencing technologies. Knowledge on genetic background can be applied to guide targeted ... -
A deep learning approach to predicting potential virus species crossover using convolutional neural networks and viral protein sequence patterns
(University of the Western Cape, 2022)Medical science has made substantial progress toward diagnosing, understanding the pathogenesis, and treating various causative agents of infectious disease; however, novel microbial pathogens continue to emerge, and ... -
Detection of positive selection resulting from Nevirapine treatment in longitudinal HIV-1 reverse transcriptase sequences
(University of the Western Cape, 2006)Nevirapine (NVP) is a cheap anti-retroviral drug used in poor countries worldwide, administered to pregnant women at the onset of labour to inhibit HIV enzyme reverse transcriptase. Viruses which may get transmitted to ... -
Development and implementation of ontology-based systems for mammalian gene expression profiling
(2009)The use of ontologies in the mapping of gene expression events provides an effective and comparable method to determine the expression profile of an entire genome across a large collection of experiments derived from ... -
Development and implementation of ontology-based systems for mammalian gene expression profiling
(University of the Western Cape, 2009)The use of ontologies in the mapping of gene expression events provides an effective and comparable method to determine the expression profile of an entire genome across a large collection of experiments derived from ... -
"Development and implementation of ontology-based systems for mammalian gene expression profiling"
(University of the Western Cape, 2009)The use of ontologies in the mapping of gene expression events provides an effective and comparable method to determine the expression profile of an entire genome across a large collection of experiments derived from ... -
Development of a comprehensive annotation and curation framework for analysis of Glossina Morsitans Morsitans expresses sequence tags
(University of the Western Cape, 2011)This study has successfully identified transcripts differentially expressed in the salivary gland and midgut and provides candidate genes that are critical to response to parasite invasion. Furthermore, an open-source ... -
Development of a data processing toolkit for the analysis of next-generation sequencing data generated using the primer ID approach
(University of the Western Cape, 2018)Sequencing an HIV quasispecies with next generation sequencing technologies yields a dataset with significant amplification bias and errors resulting from both the PCR and sequencing steps. Both the amplification bias ... -
Development of a hepatitis C virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
(2011)To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ... -
Development of a Hepatitis C Virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
(University of the Western Cape, 2011)To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ... -
Development of a simple artificial intelligence method to accurately subtype breast cancers based on gene expression barcodes
(University of the Western Cape, 2018)INTRODUCTION: Breast cancer is a highly heterogeneous disease. The complexity of achieving an accurate diagnosis and an effective treatment regimen lies within this heterogeneity. Subtypes of the disease are not simply ... -
The development of a single nucleotide polymorphism database for forensic identification of specified physical traits
(University of the Western Cape, 2009)Many Single Nucleotide Polymorphisms (SNPs) found in coding or regulatory regions within the human genome lead to phenotypic differences that make prediction of physical appearance, based on genetic analysis, potentially ...