Browsing South African National Bioinformatics Institute (SANBI) by Title
Now showing items 37-56 of 84
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Effects of nucleotide variation on the structure and function of human arylamine n-acetyltransferase 1
(2012)The human arylamine N-acetyltransferase 1 (NAT1) is critical in determining the duration of action and pharmacokinetics of amine-containing drugs such as para-aminosalicylic acid and para-aminobenzoyl glutamate used in ... -
Enabling the processing of bioinformatics workflows where data is located through the use of cloud and container technologies
(University of the Western Cape, 2019)The growing size of raw data and the lack of internet communication technology to keep up with that growth is introducing unique challenges to academic researchers. This is especially true for those residing in rural ... -
Establishing a framework for an African Genome Archive
(University of Western Cape, 2019)The generation of biomedical research data on the African continent is growing, with numerous studies realizing the importance of African genetic diversity in discoveries of human origins and disease susceptibility. The ... -
An evaluation of galaxy and ruffus-scripting workflows system for DNA-seq analysis
(University of the Western Cape, 2018)Functional genomics determines the biological functions of genes on a global scale by using large volumes of data obtained through techniques including next-generation sequencing (NGS). The application of NGS in biomedical ... -
Evolution of HIV-1 subtype C gp120 envelope sequences in the female genital tract and blood plasma during acute and chronic infection
(University of the Western Cape, 2014)Heterosexual transmission of HIV-1 via the female genital tract is the leading route of HIV infection in sub-Saharan Africa. Viruses then traffic between the cervical compartment and blood ensuring pervasive infection. ... -
An evolutionary genomics approach towards analysis of genes implicated in transmission of trypanosomes between tsetse fly and mammalian host
(2009)Human African trypanosomiasis is the world’s third most important parasitic disease affecting human health after malaria and schistosomiaisis. The world health organization estimates approximately 60 million people at risk ... -
Exploring the influence of organisational, environmental, and technological factors on information security policies and compliance at South African higher education institutions: Implications for biomedical research.
(University of the Western Cape, 2020)Headline reports on data breaches worldwide have resulted in heightened concerns about information security vulnerability. In Africa, South Africa is ranked among the top ‘at-risk’ countries with information security ... -
Exploring the influence of organisational, environmental, and technological factors on information security policies and compliance at South African higher education institutions: Implications for biomedical research.
(University of Western Cape, 2020)Headline reports on data breaches worldwide have resulted in heightened concerns about information security vulnerability. In Africa, South Africa is ranked among the top ‘at-risk’ countries with information security ... -
Exploring the role of the “glycan-shield” of human immunodeficiency virus in susceptibility to, and escape from, broadly neutralising antibodies
(University of the Western Cape, 2018)The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune response and a critical vaccine candidate. However, Env is densely glycosylated and thereby substantially protected from neutralisation. ... -
Generation of a human gene index and its application to disease candidacy
(University of the Western Cape, 2001)With easy access to technology to generate expressed sequence tags (ESTs), several groups have sequenced from thousands to several thousands of ESTs. These ESTs benefit from consolidation and organization to deliver ... -
Genome-wide annotation of chemosensory and glutamate-gated receptors, and related genes in Glossina morsitans morsitans tsetse fly
(University of the Western Cape, 2014)Tsetse flies are the sole vectors of trypanosomes that cause nagana and sleeping sickness in animals and humans respectively in tropical Africa. Tsetse are unique: both sexes adults are exclusive blood-feeders, females are ... -
Genomic epidemiology of Rift Valley fever in East Africa
(University of the Western Cape, 2023)Rift Valley fever (RVF) is a climate-driven zoonotic disease of significant importance to public and livestock health given its epidemic potential. The disease was first identified in 1930 in the great rift valley region ... -
High performance computing and algorithm development: application of dataset development to algorithm parameterization
(University of the Western Cape, 2006)A number of technologies exist that captures data from biological systems. In addition, several computational tools, which aim to organize the data resulting from these technologies, have been created. The ability of these ... -
HIV subtype C diversity: analysis of the relationship of sequence diversity to proposed epitope locations
(University of the Western Cape, 2002)Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIVÂ’s biology and rapid mutation rate have made vaccine ... -
HIV Subtype C Diversity: Analysis of the Relationship of Sequence Diversity to Proposed Epitope Locations
(University of the Western Cape, 2002)Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIV's biology and rapid mutation rate have made vaccine ... -
Identification and characterization of microRNAs and their putative target genes in Anopheles funestus s.s
(2013)The discovery of microRNAs (miRNAs) is one of the most exciting scientific breakthroughs in the last decade. miRNAs are short RNA molecules that do not encode proteins but instead, regulate gene expression. Over the past ... -
Identification and ranking of pervasive secondary structures in positive sense single-stranded ribonucleic acid viral genomes
(University of the Western Cape, 2018)The plasticity of single-stranded viral genomes permits the formation of secondary structures through complementary base-pairing of their component nucleotides. Such structures have been shown to regulate a number of ... -
The identification of biologically important secondary structures in disease-causing RNA viruses
(University of the Western Cape, 2012)Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ... -
The identification of biologically important secondary structures in disease-causing RNA viruses.
(University of the Western Cape, 2012)Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ... -
Identification of coding variants associated with familial systemic lupus erythematosus through whole exome sequencing
(University of the Western Cape, 2016)Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by the production of a wide range of autoantibodies directed against selfantigens. SLE can influence almost any organ system and ...