Browsing South African National Bioinformatics Institute (SANBI) by Author "Christoffels, Alan"
Now showing items 1-20 of 40
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Baobab LIMS: An open source biobank laboratory information management system for resource-limited settings
Bendou, Hocine (University of the Western Cape, 2019)A laboratory information management system (LIMS) is central to the informatics infrastructure that underlies biobanking activities. To date, a wide range of commercial and open source LIMS are available. The decision ... -
Coding of tsetse repellents by olfactory sensory neurons: towards the improvement and the development of novel
Souleymane, Diallo (University of the Western Cape, 2020)Tsetse flies are the biological vectors of human and animal trypanosomiasis and hence representant medical and veterinary importance. The sense of smell plays a significant role in tsetse and its ecological interaction, ... -
Coding of tsetse repellents by olfactory sensory neurons: towards the improvement and the development of novel tsetse repellents
Souleymane, Diallo (University of the Western Cape, 2020)Tsetse flies are the biological vectors of human and animal trypanosomiasis and hence representant medical and veterinary importance. The sense of smell plays a significant role in tsetse and its ecological interaction, ... -
Coding of tsetse repellents by olfactory sensory neurons: towards the improvement and the development of novel tsetse repellents
Souleymane, Diallo (University of Western Cape, 2021)Tsetse flies are the biological vectors of human and animal trypanosomiasis and hence representant medical and veterinary importance. The sense of smell plays a significant role in tsetse and its ecological interaction, ... -
A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
Mpondo, Feziwe (2009)Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly ... -
A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
Mpondo, Feziwe (University of the western cape, 2009)Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly ... -
Computational characterisation of DNA methylomes in mycobacterium tuberculosis Beijing hyper- and hypo-virulent strains
Naidu, Alecia Geraldine (University of the Western Cape, 2014)Mycobacterium tuberculosis, the causative agent of tuberculosis, is estimated to infect approximately one-third of the world’s population and is responsible for around 2 million deaths per year. The disease is endemic in ... -
A computational characterisation of the relationship between genome structure and disease genes
Kibler, Tracey Deborah (University of the Western Cape, 2012)This is a pilot study to investigate the relationship between disease gene status and the structure of the human genome with specific reference to regions of recombination. It compares certain characteristics of a control ... -
Computational characterization of IRE-regulated genes in Glossina morsitans
Dashti, Zahra Jalali Sefid (University of Western Cape, 2013)Blood feeding is a habit exhibited by many insects. Considering the devastating impact of these insects on human health, it is important to focus research on understanding the biology behind blood-feeding, disease ... -
Computational strategies to identify, prioritize and design potential antimalarial agents from natural products
Egieyeh, Samuel Ayodele (University of the Western Cape, 2015)Introduction: There is an exigent need to develop novel antimalarial drugs in view of the mounting disease burden and emergent resistance to the presently used drugs against the malarial parasites. A large amount of natural ... -
Data Science techniques for predicting plant genes involved in secondary metabolites production
Muteba, Ben Ilunga (University of the Western Cape, 2018)Plant genome analysis is currently experiencing a boost due to reduced costs associated with the development of next generation sequencing technologies. Knowledge on genetic background can be applied to guide targeted ... -
Development of a comprehensive annotation and curation framework for analysis of Glossina Morsitans Morsitans expresses sequence tags
Wamalwa, Mark (University of the Western Cape, 2011)This study has successfully identified transcripts differentially expressed in the salivary gland and midgut and provides candidate genes that are critical to response to parasite invasion. Furthermore, an open-source ... -
Development of a hepatitis C virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
Samuel, Kojo Kwofie (2011)To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ... -
Development of a Hepatitis C Virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
Kojo, Kwofie Samuel (University of the Western Cape, 2011)To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ... -
Development of an operon detection algorithm to analyze gene regulation in drug resistant Mycobacterium tuberculosis
Calvert-Joshua, Tracey (University of the Western Cape, 2022)In prokaryotes, operon structures often form to allow microorganisms to respond rapidly and efficiently to changing environmental conditions. Operons are sets of neighbouring genes which are co-regulated and co-transcribed. ... -
Development of Open source Laboratory Information Management System (LIMS) For Human Biobanking
Ademuyiwa, Toluwaleke (University of the Western Cape, 2018)Biobanks are collections of biological samples and associated data for future use. The day to day activities in a biobank laboratory is underpinned by a laboratory information management system (LIMS). For example, the ... -
Effects of nucleotide variation on the structure and function of human arylamine n-acetyltransferase 1
Akurugu, Wisdom Alemya (2012)The human arylamine N-acetyltransferase 1 (NAT1) is critical in determining the duration of action and pharmacokinetics of amine-containing drugs such as para-aminosalicylic acid and para-aminobenzoyl glutamate used in ... -
Enabling the processing of bioinformatics workflows where data is located through the use of cloud and container technologies
de Beste, Eugene (University of the Western Cape, 2019)The growing size of raw data and the lack of internet communication technology to keep up with that growth is introducing unique challenges to academic researchers. This is especially true for those residing in rural ... -
Establishing a framework for an African Genome Archive
Southgate, Jamie (University of Western Cape, 2019)The generation of biomedical research data on the African continent is growing, with numerous studies realizing the importance of African genetic diversity in discoveries of human origins and disease susceptibility. The ... -
An evaluation of galaxy and ruffus-scripting workflows system for DNA-seq analysis
Oluwaseun, Ajayi Olabode (University of the Western Cape, 2018)Functional genomics determines the biological functions of genes on a global scale by using large volumes of data obtained through techniques including next-generation sequencing (NGS). The application of NGS in biomedical ...