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“An investigation into the MicroRNA-gene interactions involved in the pathogenesis of systemic lupus erythematosus”
(University of the Western Cape, 2015)
Systemic lupus erythematosus is a chronic, inflammatory disease characterised by the production of autoantibodies which target particularly the nuclear components of multiple cell types throughout the body. MicroRNA’s have ...
Computational strategies to identify, prioritize and design potential antimalarial agents from natural products
(University of the Western Cape, 2015)
Introduction: There is an exigent need to develop novel antimalarial drugs in view of the mounting disease burden and emergent resistance to the presently used drugs against the malarial parasites. A large amount of natural ...
The phylogeography, epidemiology and determinants of Maize streak virus dispersal across Africa and the adjacent Indian Ocean Islands
(University of the Western Cape, 2015)
Maize streak disease (MSD), caused by variants of the Maize streak virus (MSV) A strain, is the world's third and Africa’s most important maize foliar disease. Outbreaks of the disease occur frequently and in an erratic ...
Computational genomics approaches for kidney diseases in Africa
(University of the Western Cape, 2015)
End stage renal disease (ESRD), a more severe form of kidney disease, is considered to be a complex trait that may involve multiple processes which work together on a background of a significant genetic susceptibility. ...
Integrating regulatory and methylome data for the discovery of clear cell Renal Cell Carcinoma (ccRCC) variants
(University of the Western Cape, 2015)
Kidney cancers, of which clear cell renal cell carcinoma comprises an estimated 70%, have been placed amongst the top ten most common cancers in both males and females. With a mortality rate that exceeds 40%, kidney cancer ...
Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer
(University of the Western Cape, 2015)
Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a ...