Browsing Magister Scientiae - MSc (Bioinformatics) by Title
Now showing items 14-33 of 44
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Effects of nucleotide variation on the structure and function of human arylamine n-acetyltransferase 1
(2012)The human arylamine N-acetyltransferase 1 (NAT1) is critical in determining the duration of action and pharmacokinetics of amine-containing drugs such as para-aminosalicylic acid and para-aminobenzoyl glutamate used in ... -
Enabling the processing of bioinformatics workflows where data is located through the use of cloud and container technologies
(University of the Western Cape, 2019)The growing size of raw data and the lack of internet communication technology to keep up with that growth is introducing unique challenges to academic researchers. This is especially true for those residing in rural ... -
Establishing a framework for an African Genome Archive
(University of Western Cape, 2019)The generation of biomedical research data on the African continent is growing, with numerous studies realizing the importance of African genetic diversity in discoveries of human origins and disease susceptibility. The ... -
An evaluation of galaxy and ruffus-scripting workflows system for DNA-seq analysis
(University of the Western Cape, 2018)Functional genomics determines the biological functions of genes on a global scale by using large volumes of data obtained through techniques including next-generation sequencing (NGS). The application of NGS in biomedical ... -
An evolutionary genomics approach towards analysis of genes implicated in transmission of trypanosomes between tsetse fly and mammalian host
(2009)Human African trypanosomiasis is the world’s third most important parasitic disease affecting human health after malaria and schistosomiaisis. The world health organization estimates approximately 60 million people at risk ... -
Exploring the influence of organisational, environmental, and technological factors on information security policies and compliance at South African higher education institutions: Implications for biomedical research.
(University of the Western Cape, 2020)Headline reports on data breaches worldwide have resulted in heightened concerns about information security vulnerability. In Africa, South Africa is ranked among the top ‘at-risk’ countries with information security ... -
Exploring the influence of organisational, environmental, and technological factors on information security policies and compliance at South African higher education institutions: Implications for biomedical research.
(University of Western Cape, 2020)Headline reports on data breaches worldwide have resulted in heightened concerns about information security vulnerability. In Africa, South Africa is ranked among the top ‘at-risk’ countries with information security ... -
High performance computing and algorithm development: application of dataset development to algorithm parameterization
(University of the Western Cape, 2006)A number of technologies exist that captures data from biological systems. In addition, several computational tools, which aim to organize the data resulting from these technologies, have been created. The ability of these ... -
HIV subtype C diversity: analysis of the relationship of sequence diversity to proposed epitope locations
(University of the Western Cape, 2002)Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIVÂ’s biology and rapid mutation rate have made vaccine ... -
HIV Subtype C Diversity: Analysis of the Relationship of Sequence Diversity to Proposed Epitope Locations
(University of the Western Cape, 2002)Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIV's biology and rapid mutation rate have made vaccine ... -
The identification of biologically important secondary structures in disease-causing RNA viruses
(University of the Western Cape, 2012)Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ... -
The identification of biologically important secondary structures in disease-causing RNA viruses.
(University of the Western Cape, 2012)Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ... -
Identification of insertion-induced enhancers linked to gene drivers within non-coding DNA using a pipeline for diffuse large b-cell lymphoma H3K27ac ChIP-seq data
(University of the Western Cape, 2022)Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) and incorporates a diverse range of illnesses with varying biology, clinical manifestations, and therapeutic responses. Functional ... -
Incidence and regulatory implications of single Nucleotide polymorphisms among established ovarian cancer genes
(University of the Western Cape, 2009)OVARIAN cancer research focuses on answering important questions related to the disease, determining whether new approaches are feasible to contribute towards improving current treatments or discovering new ones. This study ... -
Integrating regulatory and methylome data for the discovery of clear cell Renal Cell Carcinoma (ccRCC) variants
(University of the Western Cape, 2015)Kidney cancers, of which clear cell renal cell carcinoma comprises an estimated 70%, have been placed amongst the top ten most common cancers in both males and females. With a mortality rate that exceeds 40%, kidney cancer ... -
Investigating the structural effect of Raltegravir resistance associated mutations on the South African HIV-1 Integrase subtype C protein structure
(University of the Western Cape, 2020)Background and Aims Human Immunodeficiency Virus (HIV) type 1 group M subtype C (HIV-1C) accounts for nearly half of global HIV-1 infections, with South Africa (SA) being one of the countries with the highest infection ... -
An investigation into the genetic basis of autosomal recessive Osteogenesis imperfecta (OI) III in a South African family of mixed ancestry
(University of the Western Cape, 2022)Osteogenesis Imperfecta (OI) is a rare skeletal dysplasia that is primarily characterized by bone fragility, recurrent fractures, and bone deformities. Over the years there has been an increase in the number of genes ... -
“An investigation into the MicroRNA-gene interactions involved in the pathogenesis of systemic lupus erythematosus”
(University of the Western Cape, 2015)Systemic lupus erythematosus is a chronic, inflammatory disease characterised by the production of autoantibodies which target particularly the nuclear components of multiple cell types throughout the body. MicroRNA’s have ... -
A knowledgebase of stress reponsive gene regulatory elements in arabidopsis Thaliana
(University of the Western Cape, 2011)Stress responsive genes play a key role in shaping the manner in which plants process and respond to environmental stress. Their gene products are linked to DNA transcription and its consequent translation into a response ... -
Market segmentation and factors affecting stock returns on the JSE
(2008)This study examines the relationship between stock returns and market segmentation. Monthly returns of stocks listed on the JSE from 1997-2007 are analysed using mostly the analytic factor and cluster analysis techniques. ...