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Microbial diversity and gene mining in Antarctic Dry Valley mineral soils
(University of the Western Cape, 2006)
Soil communities are regarded as among the most complex and diverse assemblages of microorganisms with estimated bacterial numbers in the order of 109-1 cells.g. Studies on extreme soils however, have reported lower cell ...
Metagenomic approaches to gene discovery
(University of the Western Cape, 2006)
The classical approach to gene discovery has been to culture micro-organisms demonstrating a specific enzyme activity and then to recover the gene of interest through shotgun cloning. The realization that these standard ...
Identification and characterisation of a novel gene, DWNN, isolated from promoter-trapped Chinese hamster ovary cells
(University of the Western Cape, 2005)
The process of cytotoxic T lymphocyte (CTL) killing involves the recognition and destruction of foreign antigens by cytotoxic T cells and is of crucial importance to the defence of the organism against viral infections. ...
The detection of meningococcal disease through identification of antimicrobial peptides using an in silico model creation
(University of the Western Cape, 2019)
Neisseria meningitidis (the meningococcus), the causative agent of meningococcal disease (MD) was identified in 1887 and despite effective antibiotics and partially effective vaccines, Neisseria meningitidis (N. meningitidis) ...
Molecular analysis of red colouration in 'Bon Rouge' pear (Pyrus communis L.)
(University of the Western Cape, 2018)
The 'Bon Rouge' pear cultivar was developed from a bud mutation on a 'Bon
Chretien' pear tree. The latter is characterised by green fruit skin and leaves,
while 'Bon Rouge' is characterised by red leaves and red fruit skin ...
Proteomic and functional characterisation of biofilm formation in Xylophilus ampelinus
(University of the Western Cape, 2019)
Xylophilus ampelinus, the causal agent of bacterial blight of grapevine, inhabits the vascular tissues
of infected plants where the cells appear to form assemblages resembling biofilms. Bacterial blight
of grapevine ...
3,3' Diindolylmethane mediated signalling and its role in Brassica napus L. responses to vanadium
(University of the Western Cape, 2016)
Anthropogenic activities such as mineral mining, improper watering practices, and
the use of heavy metal contaminated fertilizers have caused an influx of heavy
metals into arable lands. These heavy metals may have a ...
Validation and application of a highly discriminating and rapid 10-locus Y-STR DNA profiling system
(University of the Western Cape, 2019)
DNA profiling the male specific region on the Y-chromosome is fundamental to forensic practise. Its recognised as a powerful analytical tool for investigation of sexual assault when the DNA evidence is highly admixed. ...
Analysis, expression profiling and characterization of hsa-miR-5698 target genes as putative dynamic network biomarkers for prostate cancer: a combined in silico and molecular approach
(University of the Western Cape, 2019)
2018, the International Agency for Research on Cancer (IARC) estimated that prostate cancer (PCa) was the second leading cause of death in males worldwide. The number of deaths are expected to raise by 50 % in the next ...
MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches
(University of the Western Cape, 2019)
Colorectal cancer (CRC) is referred to as cancers that arise in the colon or rectum. Rectal cancer
is most often defined as cancers originating within 15 cm from the anal verge. The crude
incidence of CRC in sub-Sahara ...