Now showing items 1-6 of 6
Determination of plasma concentrations using LC/MS and pharmacokinetics of ofloxacin in patients with multi-drug resistant tuberculosis and in patients with multi-drug resistant tuberculosis coinfected with hiv
Many studies have investigated the pharmacokinetics of anti-tuberculosis drugs in patients infected with tuberculosis. However, little is known about the pharmacokinetics of the drugs that are used in the treatment of ...
Determination of pyrazinamide plasma concentrations using lc-ms and pharmacokinetics of pyrazinamide in patients with multidrug-resistant tuberculosis and in patients co-infected with multidrug-resistant tuberculosis and HIV
Tuberculosis and HIV are arguably South Africa’s largest and most important health issues. With drug-resistant strains of tuberculosis on the increase and little research on new drugs, there is an urgent need for research ...
Determination of kanamycin plasma concentrations using LC/MS and pharmacokinetics of kanamycin in patients with multidrug-resistant tuberculosis and in patients with multidrug-resistant tuberculosis co-infected with HIV
(University of the Western Cape, 2012)
The aim of the study was to determine firstly, kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC/MS); secondly, to investigate the PK parameters of kanamycin in patients infected ...
Formulation of a nevirapine co-crystal as a liquid dosage form
(University of the Western Cape, 2016)
Co-crystals are a solid phase phenomena that could enhance the physicochemical properties of an active pharmaceutical ingredient. A co-crystal has never been incorporated into a liquid dosage form with the assurance of ...
Ethionamide pharmacokinetics in multidrugresistant tuberculosis patients with and without HIVinfection
(University of the Western Cape, 2017)
Many studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs in tuberculosis patients. However, currently in South Africa, no studies have been done on ethionamide (ETH) PK in adult MDR-TB patients ...
Cheminformatic approaches to hit-prioritization and target prediction of potential anti-mrsa natural products
(University of Western Cape, 2020)
The growing resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) to currently prescribed drugs has resulted in the failure of prevention and treatment of different infections caused by the superbug. Therefore, ...