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Comparison of the physicochemical characteristics and flavonoid release profiles of Sutherlandia frutescens phytosomes versus liposomes
(University of the Western Cape, 2016)
Sutherlandia frutescens is a traditional plant medicine widely used in South Africa. Traditionally, the leaves of S. frutescens are mainly used as a tea, but these traditional dosage forms have several disadvantages, ...
Hybrid molecules as inhibitors of the monoamine oxidases and caspase 3 for neurodegenerative disorders
(University of the Western Cape, 2016)
Neurodegenerative diseases are multifactorial in nature, and taking the complex nature of these disorders into consideration, multi-target directed ligands may present as better options to treat these disorders than the ...
Formulation and evaluation of zidovudine cyclodextrin inclusion complex to enhance acid lability and palatability
(University of the Western Cape, 2016)
Background: Zidovudine (AZT) is a very useful drug for the management of Human
Immunodeficiency Virus (HIV) infection. Its optimal use is limited by its bitter taste, sparing solubility (20.1 mg/ml) and acid lability. ...
A qualitative evaluation on the appropriateness of the current regulatory guidelines, on the manufacture of medicines within the radiopharmaceutical industry
(University of the Western cape, 2016)
The purpose of this research thesis, is to evaluate the appropriateness of the current regulatory guidelines on the manufacture of medicinal products within the radiopharmaceutical industry. The manufacture of radiopharmaceuticals ...
Investigation of the antidiabetic activity of Cnicusbenedictus L. in rats
(University of the Western Cape, 2016)
Diabetes Mellitus, one of the major diseases affecting human population all over the
world has caused significant morbidity and mortality. The management of this
condition has raised the demand of safe and cost effective ...
Evaluation of the anticonvulsant activity of Elytropappus rhinocerotis (L.f) Less
(University of the Western Cape, 2016)
M.Pharm thesis, Discipline of Pharmacology, School of Pharmacy, University of the Western
Cape. Epilepsy is a worldwide neurological disorder which is also prevalent in South Africa. Herbal
medicines, besides orthodox ...
Formulation of a nevirapine co-crystal as a liquid dosage form
(University of the Western Cape, 2016)
Co-crystals are a solid phase phenomena that could enhance the physicochemical properties of an active pharmaceutical ingredient. A co-crystal has never been incorporated into a liquid dosage form with the assurance of ...
Synthesis and evaluation of novel coumarin-donepezil derivatives as dual acting monoamine oxidase B and cholinesterase in Alzheimer's disease
(University of the Western Cape, 2016)
Alzheimer's disease is a progressive neurodegenerative disease characterised by low acetylcholine (ACh) levels in the hippocampus and cortex of the brain, causing symptoms like progressive memory loss, decline in language ...
Evaluation of the effect of polyethylene glycol incorporation on the performance of poly(lactic-co-glycolic acid) nanoparticles
(University of the Western Cape, 2016)
Nanoparticle drug delivery is challenged by the binding of proteins in
blood which result in their rapid removal from the circulatory system. Nanoparticles
engineered to delay protein binding have shown to have extended ...
Tacrine, trolox and tryptoline as lead compounds for the design and synthesis of multi-target drugs for Alzheimer's disease therapy
(University of the Western Cape, 2016)
The cascade of neurotoxic events involved in the pathogenesis of Alzheimer's disease may explain the inefficacy of currently available treatment based on acetylcholinesterase inhibitors (AChEI - donepezil, galantamine, ...