Browsing Magister Pharmaceuticae - MPharm by Issue Date
Now showing items 21-40 of 94
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An assessment of current practice patterns of TB/HIV at primary healthcare clinics in the Western Cape and a needs assessment for clinic-based training among final year Pharmacy students
(University of the Western Cape, 2010)Tuberculosis (TB) is a major contributor to the disease burden in developing countries resulting in deaths of approximately 2 million people a year. South Africa (SA) has one of the highest annual TB incidences with an ... -
Pharmaceutical evaluation of phela capsules Used as traditional medicine
(University of the Western Cape, 2010)In conclusion, the results obtained firstly indicated that the BP, EMEA and WHO were in fairly good agreement on the criteria and specifications that can be used to assesses the pharmaceutical quality of a traditional plant ... -
Pharmacological evaluation of antidiarrhoeal and antidiabetic activities of Syzygium Cordatum Hochst. ex C. Krauss
(University of the Western Cape, 2011)Syzygium cordatum is a medicinal plant indigenous to South Africa and Mozambique, commonly used to treat stomach aches, diabetes, respiratory problems and tuberculosis. In spite of the folklore use, adequate scientific ... -
Pharmaceutical formulation and in-vitro testing of Dioxy MP 14 (stabilised chlorine dioxide) against mycobacteria tuberculosis
(University of the Western Cape, 2011)This study was based on Dioxy MP 14 (DMP), a brand of stabilized chlorine dioxide (SCD). The active pharmaceutical ingredient (API) of DMP is chlorine dioxide (CD) which is a potent oxidant and biocide. These properties ... -
Evaluation of the antinociceptive, anti-inflammatory and antipyretic activities of Ruta Graveolens L. in mice and rats
(University of the Western Cape, 2012)Evaluation of the antinociceptive, anti-inflammatory and antipyretic activities of Ruta graveolens L. in mice and rats FIRDOWS LOONAT M. Pharm. Pharmaceutical Sciences thesis: School of Pharmacy, University of the Western ... -
Inter-professional collaboration between general practitioners and community pharmacists: general practitioners’ perspectives
(University of Western Cape, 2012)The global movement towards enhancing inter-professional collaboration in patient care is in light of the increasing potency of drugs and complexity of drug regimens, particularly in the chronically ill where poly-pharmacy ... -
Treatment outcomes in patients infected with multidrug resistant tuberculosis and in patients with multidrug resistant tuberculosis coinfected with human immunodeficiency virus at Brewelskloof Hospital
(University of the Western Cape, 2012)Many studies have reported low cure rates for multidrug-resistant tuberculosis (MDRTB) patients and MDR-TB patients co-infected with human immunodeficiency virus (HIV). However, little is known about the effect of HIV ... -
Determination of kanamycin plasma concentrations using LC/MS and pharmacokinetics of kanamycin in patients with multidrug-resistant tuberculosis and in patients with multidrug-resistant tuberculosis co-infected with HIV
(University of the Western Cape, 2012)The aim of the study was to determine firstly, kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC/MS); secondly, to investigate the PK parameters of kanamycin in patients infected ... -
Development of a model to predict the cost of management of diabetes mellitus and its complications at Groote Schuur Hospital
(University of the Western Cape, 2012)Diabetes mellitus places a substantial financial burden on the funder for treatment of this disease. This burden is compounded by the development of diabetes mellitus related complications. The cost of management of diabetes ... -
The effect of co-crystallization and polymorphism on the physicochemical properties of amoxicillin tri-hydrate
(University of the Western Cape, 2013)Many active pharmaceutical ingredients (APIs) have poor physicochemical properties such as solubility, dissolution and chemical stability. Several strategies are used to enhance and improve these properties of the API. ... -
Determination of pyrazinamide plasma concentrations using lc-ms and pharmacokinetics of pyrazinamide in patients with multidrug-resistant tuberculosis and in patients co-infected with multidrug-resistant tuberculosis and HIV
(2013)Tuberculosis and HIV are arguably South Africa’s largest and most important health issues. With drug-resistant strains of tuberculosis on the increase and little research on new drugs, there is an urgent need for research ... -
Examining the inventory management of antiretroviral drugs at community health centres in the cape metropole, Western Cape
(2013)South Africa is faced with a high number of people living with HIV/AIDS, and subsequently a great need to access quality medicines for improving patient therapeutic outcomes. Antiretroviral drugs (ARVs) require rigid, ... -
Is paracetamol being prescribed and used at the correct therapeutic dose in the children population in South Africa?
(University of the Western Cape, 2014)When used at the recommended and approved therapeutic dose, paracetamol is effective. Paracetamol is available in various forms and easily accessible from general dealers and pharmacies. The liquid form is the preferred ... -
Dissolution and antiviral activity of a novel nevirapine formulation
(University of the Western Cape, 2014)The author’s objective was to follow the product life-cycle process of a novel antiretroviral, nevirapine formulation in South Africa, to generate and compile data to pursue market registration. Five supramolecular ... -
A crystal engineering study of selected sulfa drugs and trimethoprim
(University of the Western Cape, 2014)The objective was to prepare new solid phases, i.e. co-crystal forms, of two sulfa antibiotic drugs (sulfamethoxazole and sulfasalazine) with trimethoprim and fourteen potential co-formers with GRAS status. Trimethoprim ... -
Investigation of the in vitro bioavailability of luteolin from modified preparations of Artemisia afra
(University of the Western Cape, 2014)Artemisia afra (A. afra) is traditionally used for a variety of ailments and contain flavonoids e.g. luteolin which may contribute to some of its activity. It is generally administered as a tea or decoction, and such liquid ... -
Monitoring lipid and haematological abnormalities in paediatric patients on antiretroviral therapy at a Community Health Centre in the Cape Metropole
(University of the Western Cape, 2014)South Africa faces a huge Human Immunodeficiency Virus (HIV) burden with more than 400,000 children currently on antiretroviral therapy (ART). Studies on lipid and haematological profile changes in paediatrics are of ... -
Prescribing practice at a tertiary level paediatric hospital in South Africa
(University of the Western Cape, 2014)The objectives of the present study were to describe the type and frequency of prescribing errors and error frequency, to determine the error frequency for different drug classes, to identify potential drug interactions ... -
Novel aminoquinoline-polycyclic hybrid molecules as potential antimalarial agents
(University of the Western Cape, 2014)Plasmodium falciparum malaria continues to be a worldwide health problem, especially in developing countries in Africa and is responsible for over a million fatalities per annum. Chloroquine (CQ) is low-cost, safe and was ... -
Challenges facing researchers conducting clinical trials in HIV prevention in South Africa: a focus on adherence
(University of the Western Cape, 2014)In clinical trials, adherence of the participants to the dosing instructions is a major challenge. Many researchers have identified medication adherence as a topic to further explore in order to obtain good, usable and ...
