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The development of functionalized metallic nanoparticles for the treatment of brain cancer
(University of the Western Cape, 2019)
Cancers of the nervous system often result from abnormal and uncontrolled growth of cells in nervous tissue. Glioblastoma Multiforme (GBM) and neuroblastoma (NB) are among the most common nervous system-associated cancers ...
In vitro investigation of putative interactions between the RING finger domain of Retinoblastoma Binding Protein 6 (RBBP6) and various substrates
(University of the Western Cape, 2015)
Retinoblastoma Binding Protein 6 (RBBP6) is a RING finger-containing protein which plays a critical role in the 3'-end processing of mRNA transcripts. It is a constituent of the human pre-mRNA processing complex but also ...
In vitro investigation of the ubiquitination and degradation of p53 by Murine Double Minute 2 (MDM2) and Retinoblastoma Binding Protein 6 (RBBP6)
(University of the Western Cape, 2015)
P53 is one of the most important tumour suppressor proteins in the body which protects the cell against the tumourigenic effects of DNA damage by initiating processes such as apoptosis, senescence and cell cycle arrest. ...
Characterisation of N-terminal fragments of Retinoblastoma Binding Protein 6 for structural analysis
(University of the Western Cape, 2016)
Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa RING finger-containing protein that plays a role in 3'-end poly-adenylation of mRNA transcripts as well as acting as an E3 ubiquitin ligase against a number of proteins ...
Evaluating the specancer cell targeting peptides for applications in cancer diagnostics
(University of the Western Cape, 2013)
Cancer is a disease most often associated with poor prognosis. During the development of the
disease, cells acquire genetic mutations which result in changes in bio-molecules (DNA and
protein), thus altering normal ...
Evaluation of cytotoxic activity of gold nanoparticles naturally synthesised from South African indigenous medicinal plant extracts
(University of the Western Cape, 2018)
Nanotechnology has emerged as a promising field in the quest to address health conditions. Green nanotechnology is a fairly new branch of nanotechnology, which aims to produce and utilize nanomaterials in a way that is ...
Peptide functionalised gold nanorods for the selective eradication of target cells using photothermal therapy
(University of the Western Cape, 2019)
Cancer is one of the leading causes of death, worldwide. Mortality tolls are estimated to reach approximately 13.1 million in 2030. These statistics suggest that current therapeutic strategies are not effective. This is ...
Evaluation of the anticancer and molecular effects of green synthesized silver nanoparticles
(University of the Western Cape, 2023)
Globally, cancer is considered the second leading cause of death with a staggering tally of 10 million deaths. Breast, lung, colon, rectum and prostate cancers are amongst the most commonly diagnosed cancers. The current ...