Browsing Philosophiae Doctor - PhD (Bioinformatics) by Title
Now showing items 30-41 of 41
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Identification and characterization of microRNAs and their putative target genes in Anopheles funestus s.s
(2013)The discovery of microRNAs (miRNAs) is one of the most exciting scientific breakthroughs in the last decade. miRNAs are short RNA molecules that do not encode proteins but instead, regulate gene expression. Over the past ... -
Identification and ranking of pervasive secondary structures in positive sense single-stranded ribonucleic acid viral genomes
(University of the Western Cape, 2018)The plasticity of single-stranded viral genomes permits the formation of secondary structures through complementary base-pairing of their component nucleotides. Such structures have been shown to regulate a number of ... -
Identification of coding variants associated with familial systemic lupus erythematosus through whole exome sequencing
(University of the Western Cape, 2016)Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by the production of a wide range of autoantibodies directed against selfantigens. SLE can influence almost any organ system and ... -
Investigating genetic diversity and microRNA of Hermetia illucens (the black soldier fly) to breed for mass production of a novel sustainable protein
(University of the Western Cape, 2023)Introduction: A new sustainable source of protein is needed to meet the demands of the growing global population. Insect meal is a suitable replacement, and the black soldier fly (BSF) is the most used insect in industrial ... -
Irradiation induced effects on 6h-SIC
(University of the Western Cape, 2012)The framework agreement in the year 2000 by the international community to launch Generation IV program with 10 nations, to develop safe and reliable nuclear reactors gave rise to the increased interest in the studies of ... -
Management and analysis of HIV -1 ultra-deep sequence data
(University of the Western Cape, 2014)The continued success of antiretroviral programmes in the treatment of HIV is dependent on access to a cost-effective HIV drug resistance test (HIV-DRT). HIVDRT involves sequencing a fragment of the HIV genome and ... -
Modulation of soybean and maize antioxidant activities by Caffeic acid and nitric oxide under salt stress
(University of the Western Cape, 2012)This study explores the roles of exogenously applied nitric oxide, exogenously applied caffeic acid and salt stress on the antioxidant system in cereal (exemplified by maize) and legume (using soybean as an example) plants ... -
Next generation sequencing approaches for novel gene discovery in South African Parkinson’s disease families
(University of the Western Cape, 2022)In the last decade, next-generation sequencing (NGS) approaches have revolutionised the study of human genomics, particularly aiding the understanding of genetic diseases. Parkinson’s disease (PD) is a complex neurodegenerative ... -
Novel genomic biomarkers for pediatric and adult acute myeloid leukemia
(University of the Western Cape, 2023)Acute myeloid leukemia (AML) is a heterogeneous type of blood cancer that affects individuals of all ages. AML patients are categorized into favorable, intermediate, and adverse risks based on patients' genomic features ... -
Observations on the ecology and life-history of Chrysaora fulgida (Reynaud 1830) (Scyphozoa: Semaeostomeae) and other pelagic cnidarians in the inshore waters off central Namibia
(University of the Western Cape, 2019)Although jellyfish are recognised recently as key components that can influence ecosystem functioning and trophic flows in the northern Benguela upwelling ecosystem, the number of published studies on their abundance, ... -
Optimisation of proteomics techniques for archival tumour blocks of a South African cohort of colorectal cancer
(University of Western Cape, 2020)Tumour-specific protein markers are usually present at elevated concentrations in patient biopsy tissue; therefore tumour tissue is an ideal biological material for studying cancer proteomics and biomarker discovery studies. ... -
Prediction of antimicrobial peptides using hyperparameter optimized support vector machines
(University of the Western Cape, 2011)Antimicrobial peptides (AMPs) play a key role in the innate immune response. They can be ubiquitously found in a wide range of eukaryotes including mammals, amphibians, insects, plants, and protozoa. In lower organisms, ...