Browsing Philosophiae Doctor - PhD (Bioinformatics) by Author "Christoffels, Alan"
Now showing items 1-20 of 21
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Baobab LIMS: An open source biobank laboratory information management system for resource-limited settings
Bendou, Hocine (University of the Western Cape, 2019)A laboratory information management system (LIMS) is central to the informatics infrastructure that underlies biobanking activities. To date, a wide range of commercial and open source LIMS are available. The decision ... -
Coding of tsetse repellents by olfactory sensory neurons: towards the improvement and the development of novel
Souleymane, Diallo (University of the Western Cape, 2020)Tsetse flies are the biological vectors of human and animal trypanosomiasis and hence representant medical and veterinary importance. The sense of smell plays a significant role in tsetse and its ecological interaction, ... -
Coding of tsetse repellents by olfactory sensory neurons: towards the improvement and the development of novel tsetse repellents
Souleymane, Diallo (University of the Western Cape, 2020)Tsetse flies are the biological vectors of human and animal trypanosomiasis and hence representant medical and veterinary importance. The sense of smell plays a significant role in tsetse and its ecological interaction, ... -
Coding of tsetse repellents by olfactory sensory neurons: towards the improvement and the development of novel tsetse repellents
Souleymane, Diallo (University of Western Cape, 2021)Tsetse flies are the biological vectors of human and animal trypanosomiasis and hence representant medical and veterinary importance. The sense of smell plays a significant role in tsetse and its ecological interaction, ... -
Computational characterisation of DNA methylomes in mycobacterium tuberculosis Beijing hyper- and hypo-virulent strains
Naidu, Alecia Geraldine (University of the Western Cape, 2014)Mycobacterium tuberculosis, the causative agent of tuberculosis, is estimated to infect approximately one-third of the world’s population and is responsible for around 2 million deaths per year. The disease is endemic in ... -
Computational characterization of IRE-regulated genes in Glossina morsitans
Dashti, Zahra Jalali Sefid (University of Western Cape, 2013)Blood feeding is a habit exhibited by many insects. Considering the devastating impact of these insects on human health, it is important to focus research on understanding the biology behind blood-feeding, disease ... -
Computational strategies to identify, prioritize and design potential antimalarial agents from natural products
Egieyeh, Samuel Ayodele (University of the Western Cape, 2015)Introduction: There is an exigent need to develop novel antimalarial drugs in view of the mounting disease burden and emergent resistance to the presently used drugs against the malarial parasites. A large amount of natural ... -
Development of a comprehensive annotation and curation framework for analysis of Glossina Morsitans Morsitans expresses sequence tags
Wamalwa, Mark (University of the Western Cape, 2011)This study has successfully identified transcripts differentially expressed in the salivary gland and midgut and provides candidate genes that are critical to response to parasite invasion. Furthermore, an open-source ... -
Development of a hepatitis C virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
Samuel, Kojo Kwofie (2011)To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ... -
Development of a Hepatitis C Virus knowledgebase with computational prediction of functional hypothesis of therapeutic relevance
Kojo, Kwofie Samuel (University of the Western Cape, 2011)To ameliorate Hepatitis C Virus (HCV) therapeutic and diagnostic challenges requires robust intervention strategies, including approaches that leverage the plethora of rich data published in biomedical literature to gain ... -
Development of an operon detection algorithm to analyze gene regulation in drug resistant Mycobacterium tuberculosis
Calvert-Joshua, Tracey (University of the Western Cape, 2022)In prokaryotes, operon structures often form to allow microorganisms to respond rapidly and efficiently to changing environmental conditions. Operons are sets of neighbouring genes which are co-regulated and co-transcribed. ... -
Evolution of HIV-1 subtype C gp120 envelope sequences in the female genital tract and blood plasma during acute and chronic infection
Ramdayal, Kavisha (University of the Western Cape, 2014)Heterosexual transmission of HIV-1 via the female genital tract is the leading route of HIV infection in sub-Saharan Africa. Viruses then traffic between the cervical compartment and blood ensuring pervasive infection. ... -
Generation of a human gene index and its application to disease candidacy
Christoffels, Alan (University of the Western Cape, 2001)With easy access to technology to generate expressed sequence tags (ESTs), several groups have sequenced from thousands to several thousands of ESTs. These ESTs benefit from consolidation and organization to deliver ... -
Genome-wide annotation of chemosensory and glutamate-gated receptors, and related genes in Glossina morsitans morsitans tsetse fly
Obiero, George Fredrick Opondo (University of the Western Cape, 2014)Tsetse flies are the sole vectors of trypanosomes that cause nagana and sleeping sickness in animals and humans respectively in tropical Africa. Tsetse are unique: both sexes adults are exclusive blood-feeders, females are ... -
Genomic and proteornic analysis of drought tolerance in sorghum
Woldesemayat, Adugna Abdi (University of the Western Cape, 2014)Drought is the most complex phenomenon that remained to be a potential and historic challenge to human welfare. It affects plant productivity by eliciting perturbations related to a pathway that controls a normal, functionally ... -
Genomic epidemiology of Rift Valley fever in East Africa
Juma, John (University of the Western Cape, 2023)Rift Valley fever (RVF) is a climate-driven zoonotic disease of significant importance to public and livestock health given its epidemic potential. The disease was first identified in 1930 in the great rift valley region ... -
Identification and characterization of microRNAs and their putative target genes in Anopheles funestus s.s
Ali, Mushal Allam Mohamed Alhaj (2013)The discovery of microRNAs (miRNAs) is one of the most exciting scientific breakthroughs in the last decade. miRNAs are short RNA molecules that do not encode proteins but instead, regulate gene expression. Over the past ... -
Investigating genetic diversity and microRNA of Hermetia illucens (the black soldier fly) to breed for mass production of a novel sustainable protein
De Raedt, Sarah Joanne (University of the Western Cape, 2023)Introduction: A new sustainable source of protein is needed to meet the demands of the growing global population. Insect meal is a suitable replacement, and the black soldier fly (BSF) is the most used insect in industrial ... -
Next generation sequencing approaches for novel gene discovery in South African Parkinson’s disease families
Pillay, Nikita Simone (University of the Western Cape, 2022)In the last decade, next-generation sequencing (NGS) approaches have revolutionised the study of human genomics, particularly aiding the understanding of genetic diseases. Parkinson’s disease (PD) is a complex neurodegenerative ... -
Optimisation of proteomics techniques for archival tumour blocks of a South African cohort of colorectal cancer
Rossouw, Sophia Catherine (University of Western Cape, 2020)Tumour-specific protein markers are usually present at elevated concentrations in patient biopsy tissue; therefore tumour tissue is an ideal biological material for studying cancer proteomics and biomarker discovery studies. ...