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Ursolic acid and oleanolic acid as novel therapeutic agents in breast cancer
(University of the Western Cape, 2015)
Breast cancer is one of the most common cancers among women in South Africa and the second leading cause of cancer death after lung cancer. According to the American Cancer Society 2015, women have a 12% chance of developing ...
The effect of nicotine and prostaglandin A2 on the lung cancer cell line NCI-H157
(2009)
Lung cancer is the most common fatal cancer in terms of both incidence and mortality in the world. The most important cause of lung cancer is exposure to
tobacco smoke through active or passive smoking. Nicotine which is ...
Apoptotic markers in ejaculated human spermatozoa
(University of the Western Cape, 2005)
The role of male germ cell death in spermatogenesis is an important one as it removes dysfunctional or genetically damaged germ cells and is necessary to maintain an optimal germ cell to Sertoli cell ratio. The formation ...
Differential toxicity of two murine endothelial cells to ROS duress: Understanding oxidative stress-induced blood-brain barrier dysfunction
(University of the Western Cape, 2020)
The blood-brain barrier (BBB) is a critical interface between the blood circulation and brain tissue which performs critical selection of circulating molecules that gain access to the brain tissue. Its unique ability to ...
Investigating the anti-cancer activity of novel phenothiazines in glioblastoma
(University of the Western Cape, 2018)
Glioblastoma multiforme (GBM) remains the most malignant of all primary adult brain tumours. It is a highly invasive and vascularized neoplasm with limited treatment options and very low survival rate. GBM tumours are ...
Role of Rutin in 1-Mtthyl-4-Phenylpyridinium toxicity: Therapeutic implications for Parkinson's disease
(University of the Western Cape, 2018)
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the
progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain.
Although the etiology of PD is not ...