Browsing Doctor Pharmaceuticae - DPharm by Title
Now showing items 4-23 of 32
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Cardiovascular effects of (13S)-9_, 13_- epoxylabda-6_(19), 15(14)diol dilactone, a diterpenoid isolated from the organic extract of leonotis leonurus leaves, in anaesthetized normotensive rats
(2009)Plants used in traditional medicines have served as sources of some of the drug compounds used in medicines today, and could still serve as leads for then development of new drugs to treat existing chronic diseases such ... -
Content levels, in vitro dissolution and predicted bioavailability of flavonoids from Sutherlandia frutescens leaf powder and aqueous extracts
(University of the Western Cape, 2015)Various formulations of the popular South African medicinal plant, Sutherlandia frutescens,are commercially available, with no documented specifications for quality assessment. With plans already underway for a clinical ... -
Design and synthesis of new scaffolds as antiproliferative agents and potential hsp90 inhibitors
(University of Western Cape, 2020)Natural products have been an important source of drugs and novel lead compounds in drug discovery. Their unique scaffolds have led to the synthesis of derivatives that continue to give rise to medicinally relevant agents. ... -
Development of rifampicin loaded in surface-modified 4.0 G PAMAM dendrimer as a novel antituberculosis pulmonary drug delivery system
(University of the Western Cape, 2020)Introduction: Tuberculosis (TB) is a serious bacterial infections caused by the Mycobacterium Tuberculosis (MTB) organism affecting mainly the lungs. Occasionally, MTB bacilli may be transported out of the pulmonary region ... -
The development, implementation and evaluation of an integrated framework for undergraduate pharmacy education in maternal and child health at the University of the Western Cape
(University of the Western Cape, 2022)The high rate of maternal and child mortality is a global health concern. Nationally, it is one of South Africa’s quadruple disease burdens. The Sustainable Development Goal 3, 2030 targets related to maternal and child ... -
Discovery of antibacterial lead compounds from marine organisms
(University of the Western Cape, 2020)Marine organisms including algae and bacteria are known to produce chemically diverse secondary metabolites for survival purposes in the marine environment. Scientists have identified some of these natural products as ... -
Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive wistar rats
(University of the Western Cape, 2011)Tulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family, Alliaceae, most commonly associated with onions and garlic. In South Africa (SA), this herb has been traditionally used in the ... -
Effects of Leonotis leonurus aqueous extract on the isolated perfused rat heart
(University of the Western Cape, 2007)An aqueous extract prepared from the leaves and smaller stems of Leonotis leonurus was used to investigate the potential effects on certain cardiovascular parameters, such as left ventricular systolic pressure, end-diastolic ... -
Evaluation of selected polycyclic compounds as resistance modulators in Mycobacterium tuberculosis
(University of the Western Cape, 2022)Progressive development of resistance to various chemotherapeutic agents used in the management of infectious diseases presents a serious problem in global public health. Increasing levels of antimicrobial resistance in ... -
Expanding presumptive male partner management of sexually transmitted infections (STIs) to Western Cape, South African community retail pharmacies
(University of the Western Cape, 2007)The effect of industrialisation has thrust the pharmaceutical profession into a clinical paradigm where the approcah to pharmaceutical decisions is more disease and patient orientated. Consequently, South African community ... -
An exploratory study of the problem of training and skills development in the public health sector: The case of two district hospitals in the Limpopo province
(University of the Western Cape, 2022)Public health sectors across the globe are usually faced with challenges of adopting creative ways to improve performance and service delivery in the form of investing in employee skills development and training. During ... -
Factors affecting the pharmacokinetics of vancomycin in children admitted to the intensive care unit (icu) of the Red Cross War Memorial Children's Hospital (RCWMCH).
(University of the Western Cape, 2023)Vancomycin is a glycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminal end of cell wall precursor units preventing the elongation and cross-linkage of the ... -
The formulation and evaluation of indomethacin tablets
(University of the Western Cape, 1998)The overall objective of this research is to attempt to produce, by direct compression, indomethacin tablets which have good dissolution characteristics and an improved bioavailability profile, when compared to the capsule ... -
The formulation of a microsphere based fixed dose combination for oral antiretroviral delivery
(University of the Western Cape, 2023)The cost of providing antiretroviral therapy (ART) remains a significant economic burden on African countries due to poverty and a lack of resources. To reduce the economic burden of HIV infection, a formulation scientist ... -
An investigation into the medicinal properties of Tulbaghia alliacea phytotherapy
(University of the Western Cape, 2009)The reproductive health of individuals is severely compromised by HIV infection, with candidiasis being the most prevalent oral complication in patients. Although not usually associated with severe morbidity, oropharyngeal ... -
An investigation into the medicinal properties of Tulbaghia alliacea phytotherapy
(University of the Western Cape, 2009)The reproductive health of individuals is severely compromised by HIV infection, with candidiasis being the most prevalent oral complication in patients. Although not usually associated with severe morbidity, oropharyngeal ... -
Investigation of common deficiencies observed in scientific assessments and the implementation of a new robust review pathway, the risk-based assessment approach, by the South African Health Regulatory Authority, SAHPRA
(University of the Western Cape, 2022)The main objective of this study is to improve patient access to medicines. The research is two-fold, the first component promotes transparency between the South African Health Products Regulatory Authority (SAHPRA), ... -
Investigation of suitable microencapsulation techniques in the preformulation of selected antiretroviral drugs
(University of the Western Cape, 2022)Background: The use of antiretroviral drugs (ARVDs) in the treatment of HIV/AIDS have been promising and effective especially amongst adults as it suppresses the viral load, thereby improving the life expectancy of HIV ... -
An investigation of the production of non-coated sustained release beads by extrusion and Spheronization
(University of the Western Cape, 1995)The popularity and increasing complexity of sustained release dosage forms has resulted in increased costs to the patient. One approach to achieve cheaper, yet effective, sustained release medication is through the ... -
Novel norbornane derivatives as potential neuroprotective agents
(University of Western Cape, 2020)Neurodegenerative disorders are characterised by progressive loss of the brain’s physiological functions as a result of gradual degeneration of neurons in the central nervous system. Even though they are classified as ...
