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    Synthesis & biological evaluation of neuroprotective molecules with polycyclic scaffolds

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    Sharma_PHD_NSC_2017.pdf (12.18Mb)
    Date
    2017
    Author
    Sharma, Rajan
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    Abstract
    Among neurological disorders, many of the most devastating disorders are neurodegenerative. Modern research associates excitotoxicity to a variety of neuropathological conditions, suggesting that the neurodegenerative diseases with distinct etiologies may have excitotoxicity as a common pathway. Excitotoxicity occurs through over-stimulation of receptors for excitatory neurotransmitters like the N-methyl-D-aspartate (NMDA) receptors. Due to the relevance of NMDA receptors and excitotoxic processes, the antagonism or modulation of NMDA receptors is used as a therapeutic tool against neurodegenerative diseases. NMDA receptor activity can be modulated by S-nitrosylation and this modulation of NMDA receptor activity can be utilised in the development of neuroprotective drugs.
    URI
    http://hdl.handle.net/11394/6228
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