Browsing Faculty of Natural Science by Subject "Sutherlandia frutescens"
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Application of Sutherlandia flutescens in cosmetic skin industry (phytochemical fingerprinting and its activity against skin immune diseases.
(University of the Western Cape, 2019)Hyperpigmentation disorders such as melasma, freckles and black-pigmented spots on the surface of the skin are often a result of increased over production and accumulation of melanin pigments in the skin. In melanin ... -
Bioactivity guided fractionation of Sutherlandia frutescens extracts for the induction of apoptosis
(University of the Western Cape, 2003)Sutherlandia frutescens popularly known as "cancer bush" or "kankerbos" is indigenous to South Africa and claimed by traditional healers to have wide therapeutic potential, most specifically against cancer. To verify these ... -
Comparison of the physicochemical characteristics and flavonoid release profiles of Sutherlandia frutescens phytosomes versus liposomes
(University of the Western Cape, 2016)Sutherlandia frutescens is a traditional plant medicine widely used in South Africa. Traditionally, the leaves of S. frutescens are mainly used as a tea, but these traditional dosage forms have several disadvantages, ... -
Comparison of the sutherlandioside B levels in two commercially available Sutherlandia frutescence preparations and the effect of elevated temperature and humidity on these levels
(University of the Western Cape, 2009)Sutherlandia frutescens (tribe Galegeae, Fabaceae), is a popular medicinal plant traditionally used in South Africa. In 2000, a company called Phyto Nova (Pty) Ltd. initiated large-scale cultivation and contract manufacturing ... -
Content levels, in vitro dissolution and predicted bioavailability of flavonoids from Sutherlandia frutescens leaf powder and aqueous extracts
(University of the Western Cape, 2015)Various formulations of the popular South African medicinal plant, Sutherlandia frutescens,are commercially available, with no documented specifications for quality assessment. With plans already underway for a clinical ... -
Effects of environmental growth conditions on the levels of sutherlandins 3 and 4 and sutherlandiosides B and D, in Sutherlandia frutescens (L.) R. Br.
(University of the Western Cape, 2011)Sutherlandia frutescens (L.) R. Br. (Fabaceae), indigenous to the Western Cape region of South Africa, is found in a Mediterranean-type climate known for its many environmental stressors that can influence the levels of ... -
Evaluation of satherlandia frutescens for anti.cancer activity
(University of the Western Cape, 2002)The claim for anti-cancer activity of the plant Sutherlandiafrutescens was investigated against some cancer cell lines in-vitro and against a dichlorvos induced chemical carcinogenesis in-vivo. A preliminary phytochemical ... -
The immune-modulating activity of Sutherlandia frutescens
(University of the Western Cape, 2010)The aim of this study was to investigate the effects of Sutherlandia frutescens on the inflammatory response and T cell differentiation in vitro using cytokines as biomarkers. Whole blood cells containing various concentrations ... -
The implementation of in vitro assays to screen environmental samples for male reproductive toxicity
(University of the Western Cape, 2010)Endocrine disrupting compounds (EDCs) are exogenous compounds/chemicals which interfere with, or have adverse effects on the production, distribution and function of natural hormones, thereby affecting normal endocrine ... -
An investigation into the antimicrobial and immune modulatory effects of Sutherlandia frutescens and Salvia africana-lutea extracts and their respective biogenic nanoparticles
(University of the Western Cape, 2020)The prevalence of cancer and antibiotic-resistant microbes has led to the necessity of affordable, efficacious, non-toxic and easily accessible therapeutic approaches. There is numerous anecdotal evidence that African ... -
Use of antioxidant activity and flavonoid levels to assess the quality of commercially available solid dose Sutherlandia frutescens products
(University of the Western Cape, 2010)The overall aims of this project were to assess the pharmaceutical quality and consistency of commercially available solid dose Sutherlandia frutescens containing products (viz. tablets & capsules) by exploring the use of ...