Browsing Department of Medical BioSciences by Title
Now showing items 145-164 of 232
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Liposomal drug delivery to brain cancer cells
(University of the Western Cape, 2015)Neuroblastomas (NBs) are the most common solid extra-cranial tumours diagnosed in childhood and characterized by a high risk of tumour relapse. Like in other tumour types, there are major concerns about the specificity and ... -
lnvestigations into the cancer modulating properties of Aspalathus linearis (Rooibos), Cyclopia intermedia (Honeybush) and Sutherlandia frutescens (Cancer bush) in oesophagea! carci nogenesis
(University of the Western Cape, 2007)This thesis contains scientific evidence on the anticancer properties of two unique South African herbal teas, rooibos and honeybush, and the herbal plant Sutherlandia frutescens (cancer bush) using an in vivo oesophageal ... -
Marine invertebrate sperm: Assessment of sperm quality using computer-aided sperm analysis
(University of Western Cape, 2020) -
Maternal nicotine expose during gestation and lactation induce premature aging of the lungs of the offspring
(University of the Western Cape, 2009)Tobacco smoking remains one of the leading causes of death worldwide. Despite all the efforts made by governments, researchers and communities to educate women about the dangerous effects of tobacco smoke and nicotine, ... -
Medicinal uses of Galenia africana: A study of the antimicrobial, antifungal and anticancer properties
(University of the Western Cape, 2017)Over the years, microorganisms have become resistant to commonly used antimicrobial agents leading to multidrug resistance. This is believed to occur even with new classes of therapeutic agents thus creating a challenge ... -
Medicinal uses of Galenia africana: A study of the antimicrobial, antifungal and anticancer properties
(University of the Western Cape, 2018)Medicinal uses of Galenia africana: A study of the antimicrobial, antifungal and anticancer properties Over the years, microorganisms have become resistant to commonly used antimicrobial agents leading to multidrug resistance. ... -
Mercury leaching from dental amalgam fillings and its association with urinary zinc
(University of the Western Cape, 2019)Mercury (Hg) is an example of a toxic metal that is not essential for nutrition. It exists in organic and inorganic forms in seafood and vapour from dental amalgam fillings respectively. Elemental mercury (Hg0) from dental ... -
Microscopic analysis of In vitro and In vivo effects of functionalized gold nanoparticles on the liver, kidney, spleen, heart and pancreas of male wistar rats
(University of the Western Cape, 2022)Nanotechnology represents a promising knowledge based platform that can solve human needs and ailments, especially in cases like cancers, diabetes, antibiotic drug resistances etc. Many metallic nanoparticles are being ... -
The modulating effect of conjugated linoleic acid (CLA) on cancer cell survival in vitro
(University of the Western Cape, 2014)Conjugated linoleic acids (CLA) are geometrical and positional isomers of n-6 octadecadenoic acid (linoleic acid, LA, 18:2n-6), which form part of a family of essential polyunsaturated fatty acids (PUFA). There are 28 ... -
The modulating effect of fatty acids on the lipid profile in colon epithelial mucosa in Vivo
(University of the Western Cape, 2009)Several abnormal conditions, including some cancers, have been associated with changes in the membrane lipid and FA composition. Dietary fat serves as a major source of lipids and FA, particularly the polyunsaturated fatty ... -
Modulation of colon carcinogenesis by dietary ω-6/ω-3 fatty acid ratios : a chemopreventive strategy?
(University of the Western Cape, 2015)The aim of this study was to determine whether dietary fats constituting specific ω-6/ω-3 fatty acids (FA) ratio has chemopreventive modulating effects on the development of colon cancer. Western diets intake of saturated ... -
Molecular genetics: strategies to identify congenital cataract genes in captive-bred vervet monkeys
(University of the Western Cape, 2013)Molecular genetics: strategies to indentify congenital cataract genes in captive-bred Vervet monkeys Zandisiwe Emilia Magwebu MSc thesis, Department of Medical Biosciences, University of the Western Cape The present ... -
Molecular genetics: strategies to identify congenital cataract genes in captive-bred Vervet monkeys
(University of the Western Cape, 2012)The present study describes molecular aspects of inherited congenital cataract in captive-bred Vervet monkeys. Congenital cataracts are lens opacities that are present at birth or soon after birth and include hereditary ... -
A molecular investigation of the prevalence of suspected periodontopathogens and their association with preterm birth
(University of the Western Cape, 2010)More than 20 million infants in the world (15.5 % of all births) are born with low birth weight. Ninety-five % of them are in developing countries. oral colonization of gram-negative anaerobes has been implicated as a risk ... -
''A molecular investigation of the prevalence of suspected periodontopathogens and their association with preterm birth.''
(University of the Western Cape, 2010)More than 20 million infants in the world (15.5 % of all births) are born with low birth weight. Ninety-five oZ of them are in developing countries. Oral colonization of Gramnegative anaerobes has been implicated as a risk ... -
Nanostructured immunosensor for low level detection of waterborne cryptosporidium
(University of the Western Cape, 2022)A major causative agent of gastrointestinal disease is Cryptosporidium, a protozoan waterborne parasite identified in over 70 countries. Cryptosporidium infection is a cause of high disease morbidity in children and the ... -
OnabotulinumtoxinA Injection for Glabellar Frown Lines as an Adjunctive Treatment for Depression
(University of the Western Cape, 2017)Depression is one of the most prevalent mental disorders worldwide. Sadness, fear and anger which are considered as negative emotions and are common in depression are coupled with the stimulation of the Corrugator supercilli ... -
Optimizing embryo culture conditions and spent culture media analysis as predictors of embryo quality and pregnancy
(University of the Western Cape, 2021)The aim of this thesis is first, to evaluate various culture conditions to improve embryo development, and secondly, to analyze spent culture media for any biomarkers that may be predictive of embryo health. Single-step ... -
Organisational commitment after a transformation process at a provincial government department
(University of the Western Cape, 2008)Organisations are by nature, dynamic entities that continuously undergo transformation in response to both internal and external pressures, which are imposed on them (Robbins, Odendaal & Roodt, 2003). Government departments ... -
Paediatric non-alcoholic fatty pancreas disease and aortic intimal medial thickness: A study identifying potential fatty infiltration of the pancreas and its association with aortic IMT in children exposed to teratogens during pregnancy
(University of the Western Cape, 2020)The incidence of non-communicable diseases is increasing worldwide, with South Africa being no exception. Non-communicable diseases are classified as non-infectious and are often referred to as lifestyle diseases as they ...