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Ursolic acid and oleanolic acid as novel therapeutic agents in breast cancer
(University of the Western Cape, 2015)
Breast cancer is one of the most common cancers among women in South Africa and the second leading cause of cancer death after lung cancer. According to the American Cancer Society 2015, women have a 12% chance of developing ...
Effect of cissampelos capensis rhizome extract on human sperm capacitation and acrosome reaction
(2013)
Cissampelos capensis, is commonly known by the Afrikaans name ‟dawidjies” or
‟dawidjieswortel”. C. capensis is the most important and best known medicinal plant
of the family Menispermaceae used by the Khoisan and other ...
The integrated effects of selected inducers of endoplasmic reticulum stress, the unfolded protein response and apoptosis on P-Glycoprotein mediated drug resistance in MCF-7 breast carcinoma cells
(University of the Western Cape, 2015)
Purpose: One of the leading causes of death reported in women worldwide is breast cancer. Manytumours, including breast cancer, associated with poor prognosis, have received a renewed focus and increased perspective with ...
The in vitro effects of nicotine and selected antibiotics, tunicamycin and thapsigargin on human Breast carcinoma (mcf-7) cells.
(University of the Western Cape, 2012)
Cancer is defined as the abnormal growth of genetically mutated or perturbant cells. Nicotine is a known cancer promoter and an apoptotic suppressor. This alkaloid acts on the nicotinic acetylcholine receptors which affects ...
The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 breast carcinoma cell line
(University of the Western Cape, 2014)
This study investigated the effects of TKIs on the growth and proliferation of MCF-7 breast carcinoma cells in culture. MCF-7 cells were exposed to different concentrations of TKIs alone and in combination with each other. ...
The effect of nicotine and prostaglandin A2 on the lung cancer cell line NCI-H157
(2009)
Lung cancer is the most common fatal cancer in terms of both incidence and mortality in the world. The most important cause of lung cancer is exposure to
tobacco smoke through active or passive smoking. Nicotine which is ...
Effect of Eurycoma longifolia (Tongkat Ali) on the prostate cancer cell line LNCaP
(2013)
Eurycoma Longfolia Jack, also known as Tongkat Ali (TA) is a tropical plant
belonging to the family of Simaroubaceae is widely distributed in South East Asian countries. The extracts of TA have been proven to have ...
Apoptotic markers in ejaculated human spermatozoa
(University of the Western Cape, 2005)
The role of male germ cell death in spermatogenesis is an important one as it removes dysfunctional or genetically damaged germ cells and is necessary to maintain an optimal germ cell to Sertoli cell ratio. The formation ...
Differential toxicity of two murine endothelial cells to ROS duress: Understanding oxidative stress-induced blood-brain barrier dysfunction
(University of the Western Cape, 2020)
The blood-brain barrier (BBB) is a critical interface between the blood circulation and brain tissue which performs critical selection of circulating molecules that gain access to the brain tissue. Its unique ability to ...
Investigating the anti-cancer activity of novel phenothiazines in glioblastoma
(University of the Western Cape, 2018)
Glioblastoma multiforme (GBM) remains the most malignant of all primary adult brain tumours. It is a highly invasive and vascularized neoplasm with limited treatment options and very low survival rate. GBM tumours are ...