Magister Scientiae - MSc (Medical BioSciences): Recent submissions
Now showing items 1-20 of 160
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The development of a sars-cov-2 pseudoparticle assay for the detection of neutralizing antibodies in sera from covid-19 patients
(University of the Western Cape, 2024)The COVID-19 pandemic has caused devastating effects on the global socio-economic landscape. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, and infections have led to ... -
The phenomenon of skin lightening among young adults, and the effect of selected plant extracts on tyrosinase and melanogenesis activity
(University of the Western Cape, 2023)Skin lightening practice refers to the use of skin lightening products to achieve a fairer skin complexion. This is common practice among people of several Asian, North American, South American countries. On the African ... -
The effect of doxorubicin encapsulated chitosan alginate nanoparticles and curcumin on multidrug resistant colon cancer cell lines
(University of the Western Cape, 2024)Purpose: Although chemotherapeutic drugs have improved the survival rate of patients diagnosed with colorectal cancer, resistance to chemotherapy frequently leads to therapeutic failure and poor patient outcomes. Multidrug ... -
Dexamethasone's impact on LPS-induced inflammation of blood-brain barrier endothelial cells
(University of the Western Cape, 2023)The blood-brain barrier (BBB) serves as a protective and regulatory barrier between the blood and the brain. Microvascular endothelial cells provide homeostatic regulation of the central nervous system (CNS). BBB integrity ... -
In vitro neuroprotective potential of phyllanthin in MPP+- induced toxicity in SH-SY5Y neuroblastoma cells
(University of the Western Cape, 2023)Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s disease, with an estimated 9 million people projected to be affected worldwide by the year 2030. PD is associated ... -
An evaluation of the biopesticidal characteristics of Helichrysum marifolium and Helichrysum patulum and their effects on animal metabolism
(University of the Western Cape, 2002)There are a number of pesticides that are suspected to be endocrine disrupters Many of these pesticides are man-made. Endocrine disrupters are chemicals that can lead to an increase in birth defects, sexual abnormalities, ... -
The effects of doxorubicin loaded chitosan-alginate nanoparticles on SK-N-BE(2) neuroblastoma cells
(University of the Western Cape, 2022)Cancer is a life-threatening disease and one of the leading causes of death globally. Cancer was thought to be associated with developed countries only but it is increasingly becoming a major health challenge in developing ... -
An electrophysiological exploration into the Sertoli cell, utilizing plant extracts with a view to contraception
(University of the western cape, 2003)Certa in medicinal plant extracts have been shown to have a contraceptive effect on male rats (Rajasekaran et al. , 1988) and mice (Kong et al., 1986). A possible site for the mechanism of action has been identified as the ... -
The influence of maternal nicotine exposure on neonatal lung development: An enzymatic and metabolic study
(University of the Western Cape, 1999)Chapter I, the literature review, gives the reader a sound background knowledge of the following: normal lung structural development in humans and rats, metabolic development with reference to structural development, tobacco ... -
The effects of Exomis micriphylla and Atriplex lindleyi on metabolism and health
(University of the Western Cape, 2002)For many decades people have used plants for healing various ailments. Plant products have been used in herbal remedies especially for their anti-infective properties. The following study was undertaken to assess the ... -
Tumour suppression and subdual of cancer (tussc) in elephants: An in vitro study to shed light on Peto’s paradox
(University of the Western Cape, 2022)Logic would suggest that cancer incidence is related to body mass and longevity. Gigantic animals such as elephants with a longer lifespan (more lifetime of cell divisions) and a larger body size (more cells) will have ... -
Structural and functional aspects of sperm after transit through the fallopian tube of the sheep
(University of the Western Cape, 1996)Ejaculated mammalian spermatozoa have the potential for fertilization. The acquisition of the ability to fertilize a fully invested oocyte occurs during the passage through the female reproductive tract. These post-ejaculatory ... -
The influence of maternal nicotine exposure on development lung as gas exchanger: the protective effect of copper
(University of the Western Cape, 1998)The influence of tobacco smoking on the developing fetus is well reported. Maternal nicotine exposure during pregnancy and lactation interferes with fetal and neonatal lung growth and development, rendering the lungs more ... -
The antioxidant properties of melatonin during chemical hypoxia and reoxygenation injury in rat ventricular myocytes
(University of the Western Cape, 2000)It is well known that ischaemia chemical hypoxia followed by reperfusion is not always accompanied by recovery of myocardial function and often produces further cell damage (Hearse et al., 1973). This phenomenon commonly ... -
The influence of maternal nicotine exposure on neonatal rat lung septal status
(University of the Western Cape, 1995)The aim of this study was to determine the effect of maternal nicotine exposure on the status of rat lung alveolar septa of 1 to 2l day old offspring. Wistar dams were injected subcutaneously, using a dosage of 1 mg ... -
Ecology and conservation of high altitude amphibians
(UWC, 2002)This study looked at the breeding ecology of the anurans, found in the Landdroskop mountain range in Grabouw, and some recommendations as to their conservation are made. There is very little known about the frogs in South ... -
Circadian activity rhythms and early gene expression in the suprachiasmatic nucleus of a diurnal rodent, Rhabdomys pumilio
(UWC, 2001)Although humans are diurnal in behavior, animal models used for the study of circadian rhythms are mainly restricted to nocturnal rodents. This study focused on circadian behavior and gene expression in a diurnal rodent ... -
Student experiences of life science practicals
(UWC, 2001)Science Educationists seem to agree that practical work should form an important component of any science course. Many students arrive at University without having been exposed to any practical work, while others were ... -
The influence of maternal nicotine exposure on neonatal lung development : an enzymatic and metabolic study
(UWC, 1999)Chapter I, the literature review, gives the reader a sound background knowledge of the following: normal lung structural development in humans and rats, metabolic development with reference to structural development, tobacco ... -
The effects of Elytropappus rhinocerotis Cass and Pelargonium triste (L.) L'Hèrit on animal health and metabolism
(University of the Western Cape, 2003)Many South Africans use cultural traditions and practices in the management of their health. Elytropappus rhinocerotis is an important medicinal plant, which is widely distributed in regions of South Africa. The objective ...
