Browsing Magister Scientiae - MSc (Biotechnology) by Author "Pretorius, Ashley"
Now showing items 1-11 of 11
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Characterization of ATP-binding cassette drug transporters and their role in breast cancer treatment using in silico approach
Hassan, Mohammed Hashim Abdalraheem (University of the Western Cape, 2019)Breast cancer is the most common cancer in women worldwide, and is the second most common cancer in the world, responsible for more than 500 000 deaths annually. Estimates are that 1 in 8 women will develop breast cancer ... -
Functional analysis of miRNA regulated genes in prostate cancer as potential diagnostic molecules
Abdullah, Gadija (University of the Western Cape, 2016)Prostate Cancer is the leading cause of cancer-related death in males in the Western world. It is a common biological disease originating from the reproductive system of the male namely, the prostate gland, usually in older ... -
Identification and validation of micrornas for diagnosing type 2 diabetes : an in silico and molecular approach
Anthony, Yancke (University of the Western Cape, 2015)Type 2 diabetes mellitus (T2DM), a metabolic disease characterized by chronic hyperglycemia, is the most prevalent form of diabetes globally, affecting approximately 95 % of the total number of people with diabetes i.e. ... -
Identification and validation of putative therapeutic and diagnostic antimicrobial peptides against HIV: An in silico approach
Tincho, Marius Belmondo (University of the Western Cape, 2013)Background: Despite the effort of scientific research on HIV therapies and to reduce the rate of HIV infection, AIDS still remains one of the major causes of death in the world and mostly in Sub-Saharan Africa. To date, ... -
Identification of biomarkers associated with cervical cancer: a combined in silico and molecular approach
Ludaka, Namhla (University of the Western Cape, 2014)Cervical cancer is the leading cause of cancer mortality among black women in South Africa. It is estimated that this disease kills approximately 8 women in South Africa every day. Cervical cancer is caused by the human ... -
Identification of microRNAs as a class of biomarkers for the early diagnosis of prostate cancer : an in silico and molecular approach
Lombe, Chipampe Patricia (University of the Western Cape, 2015)Prostate cancer (PCa) is the second most common form of cancer in men around the world. In many parts of Africa, data on prostate cancer is sparse. This is attributed to poor access to testing and diagnostics. The ... -
Identification of novel miRNAs as diagnostic and prognostic biomarkers for prostate cancer using an in silico approach
Eshibona, Nasr O.M. (University of the Western Cape, 2017)Cancer is known as uncontrollable cell growth which results in the formation of tumours in the areas that are affected by the cancer. There are two types of tumours: benign and malignant. This study focus is on prostate ... -
Identification of novel miRNAs as diagnostic molecules for detection of breast cancer using in silico approaches
Ferrara, Najua Ali (University of the Western cape, 2017)Breast cancer (BC) is the most common cancer in women worldwide, and is the second most common cancer in the world, responsible for more than 500 000 deaths annually. Estimates are that 1 in 8 women will develop BC in their ... -
Identification of potential biomarkers in lung cancer as possible diagnostic agents using bioinformatics and molecular approaches
Ahmed, Firdous (University of the Western Cape, 2015)Lung cancer remains the leading cause of cancer deaths worldwide, with the majority of cases attributed to non-small cell lung carcinomas. At the time of diagnosis, a large percentage of patients present with advanced stage ... -
Single nucleotide polymorphism association studies of ABCA13 and ABHD11 genes and the bioinformatics analysis of the autism candidate genes localized on chromosome 7
Davids, Muneera (University of the Western Cape, 2016)Autism, Aspergers Syndrome and Pervasive Developmental Delay-Not Otherwise Specified (PDD-NOS), among others, fall under an umbrella of disorders known as Autism Spectrum Disorder. Twin studies show that autism is a highly ... -
The molecular validation of miRNA's as specific biomarkers for early diagnosis of ovarian cancer
Lottering, Sharneal (University of the Western Cape, 2017)Ovarian Cancer (OC) is the most common reproductive and the most lethal gynaecological malignant tumour. The majority of Ovarian Cancers, comprising more than 95% of cases, emanate from the surface epithelium of the ovary, ...