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Homology modelling and characterization of three-dimensional (3d) protein structures of selected variants of cyp3a4
(University of the Western Cape, 2022)
The efficacy and toxicity of several drugs and prodrugs are influenced by the interindividual
genetic variations in drug-metabolising enzymes. Cytochrome P450
enzymes constitute the major metabolising enzymes in humans. ...
Synthesis and characterisation of biomimetic immunostimulatory lipid-polymer hybrid nanoparticles
(University of the Western Cape, 2022)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis),
remains a fatal infectious disease and one of the top ten leading causes of mortality,
particularly in developing countries. Current drug therapy ...
A comparison between estimated renal function from point-of care derived cystatin c measurements and serum creatinine derived measurements
(University of the Western Cape, 2022)
Serum Creatinine (SCr) is the most commonly used and cost effective
biomarker used to quantify estimated glomerular filtration rate. However, creatinine is
affected by anthropometric parameters such as muscle mass, age ...
Assessing the influence of electronic media on student perceptions towards antibiotic resistance
(University of the Western Cape, 2022)
Antimicrobial resistance (AMR) and the reduced number of new antibiotic
discoveries impose a major threat to the quality of human life and effective
treatment options. Antibiotic resistant infections require prolonged ...
The implementation of the African union model law on medical products regulation and the establishment of the African medicines agency
(University of the Western Cape, 2022)
Within Africa, there is insufficient access to quality, safe, efficacious and
affordable medical products which can partly be attributed to lack of robust
regulatory systems, a lack of competent regulatory professionals ...