Browsing Department of Medical BioSciences by Title
Now showing items 127-146 of 231
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The influence of maternal nicotine exposure on neonatal rat lung septal status
(University of the Western Cape, 1995)The aim of this study was to determine the effect of maternal nicotine exposure on the status of rat lung alveolar septa of 1 to 2l day old offspring. Wistar dams were injected subcutaneously, using a dosage of 1 mg ... -
The influence of maternal nicotine exposure on selected glycolytic and cytochrome P450 enzymes in developing neonatal rat lung
(University of the Western Cape, 2005)The structural and functional integrity of a developing and maturing fetal and neonatal lung is critically dependent on carbohydrate metabolism. The energy derived from carbohydrate metabolism is utilized during the processed ... -
The integrated effects of selected inducers of endoplasmic reticulum stress, the unfolded protein response and apoptosis on P-Glycoprotein mediated drug resistance in MCF-7 breast carcinoma cells
(University of the Western Cape, 2015)Purpose: One of the leading causes of death reported in women worldwide is breast cancer. Manytumours, including breast cancer, associated with poor prognosis, have received a renewed focus and increased perspective with ... -
The interaction between 6 MV X-rays and p(66)/Be neutrons with spherical gold nanoparticles to induce cellular damage
(University of the Western Cape, 2016)Despite the advances in therapies such as chemotherapy and radiotherapy, tumours have been shown to be resistant to the treatments. Gold nanoparticles (AuNPs) have been recognized as effective radiosensitizers of low energy ... -
Investigating effects of aqueous root extract of Mondia whitei on sperm functionality
(University of the Western Cape, 2016)Introduction: Mondia whitei commonly known as "White Ginger" is a highly acclaimed medicinal plant that is extensively used across Africa. M. whitei is used as treatment for sexual dysfunction and is considered to be an ... -
Investigating factors that influence the breeding success of the endangered African penguin (Spheniscus demersus) at a mainland and island colony in the Western Cape, South Africa
(University of Western Cape, 2022)Since the 1950s the global seabird population have declined by 70% and today some penguin species are amongst the most threatened seabirds in the world. The African penguin (Spheniscus demersus) population experienced a ... -
Investigating hypoglycaemic effects and safety of the herbal Product – JT2016 in vivo study
(University of the Western Cape, 2021)Diabetes has since been a global epidemic; an estimated 5.0 million deaths of diabetes in the world have been recorded; one in 11 adults have diabetes (415 million); and by 2040, one adult in 10 (642 million) will have ... -
Investigating hypoglycaemic effects and safety of the herbal product – jt2016 in vivo study
(University of the Western Cape, 2021)Diabetes has since been a global epidemic; an estimated 5.0 million deaths of diabetes in the world have been recorded; one in 11 adults have diabetes (415 million); and by 2040, one adult in 10 (642 million) will have ... -
Investigating novel aspects of the blood-brain barrier using high resolution electron microscopy
(University of the Western Cape, 2022)The blood-brain barrier (BBB) is a restrictive interface located between the blood circulation and the central nervous system (CNS), regulating the homeostatic environment of the neuronal milieu, by controlling the ... -
Investigating novel aspects of the blood-brain barrier using high resolution electron microscopy
(University of the Western Cape, 2022)The blood-brain barrier (BBB) is a restrictive interface located between the blood circulation and the central nervous system (CNS), regulating the homeostatic environment of the neuronal milieu, by controlling the ... -
Investigating the anti-cancer activity of novel phenothiazines in glioblastoma
(University of the Western Cape, 2018)Glioblastoma multiforme (GBM) remains the most malignant of all primary adult brain tumours. It is a highly invasive and vascularized neoplasm with limited treatment options and very low survival rate. GBM tumours are ... -
Investigating the relationship between iron deficiency and depressive symptoms in relation to the body compositions of students residing in the Western Cape
(University of the Western Cape, 2022)Iron deficiency is the consequence of a prolonged diminished iron balance, whereby iron stores are no longer sufficient to meet the requirements of regular iron turnover. It is the most ubiquitous single nutrient deficiency, ... -
An investigation into the effect of maternal exposure to nicotine and copper on neonatal lung development
(University of the Western Cape, 2006)In the 20th century, where tobacco smoking continues to be the leading preventable cause of death, an alarming number of people continue to smoke, despite awareness of the implications of exposure for themselves and those ... -
Investigation of some possible mechanisms involved in the anticonvulsant activity of Tulbaghia violacea harv
(University of the Western Cape, 2015)Even though Tulbaghia violacea has been used to treat and manage epilepsy in South Africa by traditional medicine practitioners, no evidence in any literature has shown any scientific scrutiny of the effectiveness of the ... -
Investigation of the in vitro antidiabetic and neuroprotective effects of selected Helichrysum species against high monosaccharide-induced toxicity
(University of the Western Cape, 2022)Chronic hyperglycaemia (glucotoxicity), a common complication in diabetes mellitus (DM), is known to cause cognitive decline in some of these patients, often affecting their overall quality of life. Some medicinal plants ... -
Investigations on the antifungal and cancer modulating properties of extracts from selected species of Tulbaghia
(University of the Western Cape, 2012)Fusarium verticil/ioides (Sacc) Nirenberg a common phytopathogen of maize and maize-based products produces fumonisin B (FB) mycotoxins that have been related to several diseases such as equine leukoencephalomalacia (ELEM), ... -
Investigations on the effects of Typha capensis on male reproductive functions
(University of the Western Cape, 2016)Introduction: Typha capensis, commonly referred to as bulrush also called "love reed'' growing in Southern Africa's wetlands, is one of South Africa indigenous medicinal plants that are traditionally used to treat male ... -
Investigations on the in vitro effects of aqueous Eurycoma longifolia Jack extract on male reproductive functions
(University of Western Cape, 2012)Introduction: Eurycoma longifolia (Tongkat Ali; TA) is a Malaysian shrub used to treat various illnesses including male infertility. Considering that TA is also used to improve male fertility and no report regarding ... -
Liposomal drug delivery to brain cancer cells
(University of the Western Cape, 2015)Neuroblastomas (NBs) are the most common solid extra-cranial tumours diagnosed in childhood and characterized by a high risk of tumour relapse. Like in other tumour types, there are major concerns about the specificity and ... -
lnvestigations into the cancer modulating properties of Aspalathus linearis (Rooibos), Cyclopia intermedia (Honeybush) and Sutherlandia frutescens (Cancer bush) in oesophagea! carci nogenesis
(University of the Western Cape, 2007)This thesis contains scientific evidence on the anticancer properties of two unique South African herbal teas, rooibos and honeybush, and the herbal plant Sutherlandia frutescens (cancer bush) using an in vivo oesophageal ...