Browsing Department of Medical BioSciences by Title
Now showing items 180-199 of 231
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Production of cytokines in human whole blood after incubation with the nucleocapsid protein of the NL63 Coronavirus
(University of the Western Cape, 2012-11)The Coronaviridae family consists of RNA viruses within the order Nidovirales. The family is classified into two genera, namely the corona- and toroviruses. Coronaviruses are enveloped, single stranded, positive sense ... -
Protein expression and antifungal effect of fluconazole-resistant Candida species following effective in vitro treatment with K21, a novel antifungal agent
(University of Western Cape, 2019)Background: Oropharyngeal candidiasis, caused by the fungus Candida, is the most common opportunistic infection affecting the quality of life of immunocompromised patients. Fluconazole is widely used as the first line ... -
Proteome profiling as tool to determine the effectiveness of traditional Africa therapies for Type 2 diabetes mellitus
(University of the Western Cape, 2022)Type 2 diabetes mellitus (T2DM) involves multiple organ dysfunction accompanied by a chronic inflammatory state and oxidative stress resulting from a combination of factors such as hyperglycaemia and dyslipidaemia. Although ... -
A quantitative and qualitative assessment of dental aerosols within a dental clinical unit: An avenue for the transmission of resistant nosocomial infection.
(University of Western Cape, 2020)Introduction: Nosocomial infections are infections that occur 48 hours after receiving care for an unrelated condition in a clinic or a hospital environment, many of which are resistant to at least one of the drugs most ... -
Radiation-induced Leukaemia in South Africa: Response of lymphocytes and cd34+ cells to different radiation qualities
(University of the Western Cape, 2020)Epidemiological studies have highlighted that leukaemia can be considered as the most prominent malignancy after radiation exposure during childhood. The lifetime risk on radiation-induced leukaemia for a given dose is 3 ... -
Radiation-induced leukaemia in South Africa: response of lymphocytes and cd34+ cells to different radiation qualities.
(University of the Western Cape, 2020)Epidemiological studies have highlighted that leukaemia can be considered as the most prominent malignancy after radiation exposure during childhood. The lifetime risk on radiation-induced leukaemia for a given dose is 3 ... -
Radioprotective effects of rooibos herbal tea on the developing central nervous system of wistar rats
(University of the Western Cape, 2018)Background: Early postnatal radiation exposure from environmental, diagnostic or therapeutic sources is potentially deleterious to the developing nervous system resulting in oxidative stress, structural damage, altered ... -
Radiosensitization effects of gold nanoparticles in proton therapy
(University of the Western Cape, 2017)Despite recent advances in radiotherapy, some tumours have shown to be resistant to treatment and patients still experience long term side effects. Gold nanoparticles (AuNPs) have been identified as effective radiosensitizers ... -
Red palm oil as a therapeutic agent in triple-negative breast cancer patients
(University of the Western Cape, 2020)Purpose: Breast cancer is one of the most frequent and fatal diseases women all around the globe are challenged with today. In women, breast cancer has the highest mortality rate of all cancers and the incidence rate is ... -
The relationship between "fertilizaiton environment" and structure and physiology of selected Anuran Spermatozoa
(University of the Western Cape, 1993)The propagation of species and modes of fertilization of higher vertebrates are aspects which have been extensively researched. Studies on the spermatology of lower vertebrates have not received the same attention. Anurans ... -
The relationship between male genital tract infection, oxidative status in the ejaculate, and apoptotic markers in human spermatozoa
(2009)Aim: Leukocytes are the major source of reactive oxygen species (ROS) in the ejaculate and contribute to up to 30% of male infertility. ROS have been associated with markers of apoptosis such as sperm DNA damage, ... -
A retrospective analysis of semen samples and reproductive hormones in Africa and the middle east
(University of Western Cape, 2022)Semen analysis is the cornerstone for the investigation of male infertility. Semen quality can be influenced by geographical location, age, ejaculatory abstinence, and season. In 2010, the WHO published criteria for human ... -
The role of c-reactive protein as a marker for preterm delivery
(University of Western Cape, 2020)Pregnancy associated maternal morbidity and mortality along with adverse pregnancy outcomes have gained momentum over the past few years, particularly in Sub-Saharan Africa and Southern Asia despite the advances in medical ... -
The role of high-risk human papillomavirus in periocular cancers
(University of the Western Cape, 2018)PURPOSE: High risk human papillomavirus (HR-HPV) is well established as a causative agent of squamous cell carcinoma (SCC) of the orophaynx. HR-HPV has also been reported in periocular cancers and precancers, but controversy ... -
The role of high-risk human papillomavirus in periocular cancers
(University of the Western Cape, 2018)Purpose: High risk human papillomavirus (HR-HPV) is well established as a causative agent of squamous cell carcinoma (SCC) of the orophaynx. HR-HPV has also been reported in periocular cancers and precancers, but controversy ... -
Role of Rutin in 1-Mtthyl-4-Phenylpyridinium toxicity: Therapeutic implications for Parkinson's disease
(University of the Western Cape, 2018)Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Although the etiology of PD is not ... -
The screening of phyto-pesticides for potential adverse effects on human health
(University of the Western Cape, 2010)Pesticides are designed to control or eliminate pests such as insects, rodents, weeds, bacteria, and fungi. They are used at a global scale for agricultural produce. Although pesticides play a significant role in increasing ... -
The screening of phyto-pesticides for potential adverse effects on human health
(University of the Western Cape, 2010)Pesticides are designed to control or eliminate pests such as insects, rodents, weeds, bacteria, and fungi. They are used at a global scale for agricultural produce. Although pesticides playa significant role in increasing ... -
Screening of Selected Libyan Medicinal Plants for the Synthesis of Metal Nanoparticles and their activity against Streptococcus mutans
(University of the Western Cape, 2020)Nanotechnology has emerged as an elementary division of modern science and stemmed directly from green chemistry twelve basic concepts, it receives global attention due to its unique character and ample applications. It ... -
Seasonal differences in semen characteristics and sperm functionality in Tankwa goats
(University of the Western Cape, 2018)Tankwa goats have been free-ranging in the Tankwa Karoo National Park in the Northern Cape for more than 80 years. A genetic study concluded that these feral goats are a unique genetic resource compared to other goat breeds ...