Browsing Department of Medical BioSciences by Subject "Cancer"
Now showing items 1-7 of 7
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The effect of doxorubicin encapsulated chitosan alginate nanoparticles and curcumin on multidrug resistant colon cancer cell lines
(University of the Western Cape, 2024)Purpose: Although chemotherapeutic drugs have improved the survival rate of patients diagnosed with colorectal cancer, resistance to chemotherapy frequently leads to therapeutic failure and poor patient outcomes. Multidrug ... -
Fatty acids as cancer preventive tools in the dietary modulation of altered lipid profiles associated with hepatocarcinogenesis
(University of the Western Cape, 2005)This thesis consists of a brief description on cancer, carcinogenesis, the changes in the type and level of dietary fat available in our diets over time and association with the development of certain diseases. The main ... -
Holarrhena floribunda leaves as a potential source of bioactive anticancer compounds
(University of the Western Cape, 2014)Cancer is one of the leading causes of morbidity and mortality in developed and developing nations. It is estimated that 86% of new cases and 64% of death due to cancer are from Africa and 13.1 million deaths are estimated ... -
Investigating the anti-cancer activity of novel phenothiazines in glioblastoma
(University of the Western Cape, 2018)Glioblastoma multiforme (GBM) remains the most malignant of all primary adult brain tumours. It is a highly invasive and vascularized neoplasm with limited treatment options and very low survival rate. GBM tumours are ... -
The modulating effect of conjugated linoleic acid (CLA) on cancer cell survival in vitro
(University of the Western Cape, 2014)Conjugated linoleic acids (CLA) are geometrical and positional isomers of n-6 octadecadenoic acid (linoleic acid, LA, 18:2n-6), which form part of a family of essential polyunsaturated fatty acids (PUFA). There are 28 ... -
The paracrine effect of normoxic and hypoxic cancer secretions on blood-brain barrier endothelial cells
(University of the Western Cape, 2022)Cancer is the most common leading cause of death worldwide. Glioblastoma and breast cancer are the most aggressive solid tumour. The survival rate of these tumours depends on their ability to progress and spread. These ... -
Tumour suppression and subdual of cancer (tussc) in elephants: An in vitro study to shed light on Peto’s paradox
(University of the Western Cape, 2022)Logic would suggest that cancer incidence is related to body mass and longevity. Gigantic animals such as elephants with a longer lifespan (more lifetime of cell divisions) and a larger body size (more cells) will have ...