Search
Now showing items 101-110 of 121
Identification and characterisation of cephalosporins and carbapenem-resistant Klebsiella pneumoniae isolates from Misrata, Libya
(University of the Western Cape, 2018)
Background: Extended-spectrum beta-lactamase-producing (ESBL) and carbapenemaseproducing
Gram-negative bacilli showing resistance to cephalosporins and carbapenems
respectively, have been reported from several countries ...
The role of arylamine N-acetyltransferase 1 (NAT1) in the clinical therapy of tuberculosis
(University of the Western Cape, 2017)
Despite attempts to develop new drugs to reduce the worldwide mortality rate attributable to
tuberculosis (TB), the illness remains a threat. Isoniazid (INH) has been used as a frontline
drug for decades. However, several ...
Medicinal uses of Galenia africana: A study of the antimicrobial, antifungal and anticancer properties
(University of the Western Cape, 2018)
Medicinal uses of Galenia africana: A study of the antimicrobial, antifungal and anticancer properties
Over the years, microorganisms have become resistant to commonly used antimicrobial agents leading to multidrug resistance. ...
The effects of selective inhibitors of N-Glycosylation and Endoplasmic Reticulum stress inducers on Neuroblastoma cell proliferation and Apoptosis
(University of the Western Cape, 2017)
Among all childhood cancers diagnosed, neuroblastoma (NB) is the most prevalent during
infancy. In patients younger than 15 years, it accounts for more than 7% of malignancies and
about 15% of all paediatric mortalities. ...
The potential neuroprotective effects of two South African plant extracts in hydrogen peroxide-induced neuronal toxicity
(University of the Western Cape, 2018)
Background: Oxidative stress induced by reactive oxygen species has been strongly associated with many neurodegenerative diseases (NDDs) and many medicinal plant-derived products have been reported to exert potent antioxidant ...
The role of high-risk human papillomavirus in periocular cancers
(University of the Western Cape, 2018)
PURPOSE: High risk human papillomavirus (HR-HPV) is well established as a causative agent of squamous cell carcinoma (SCC) of the orophaynx. HR-HPV has also been reported in periocular cancers and precancers, but controversy ...
Aspects of the reproduction of male and female African penguins (Spheniscus demersus) with special reference to sperm biology and cryopreservation
(University of the Western Cape, 2018)
In the marine environment, penguins have been described as curators and serve a critical role in ecological balance. The African penguin (Spheniscus demersus) has undergone a rapid population decline, mainly due to ...
Hyperglycinemia in captive-bred vervet monkeys with cataracts: genetic dynamics and associations
(University of the Western Cape, 2017)
A small percentage (8%) of the captive-bred vervet monkeys (Chlorocebus aethiops)
maintained at Primate Unit and Delft Animal Centre (PUDAC) of the South African Medical
Research Council (SAMRC) were found to have high ...
An analysis of the morphological and biological properties of a novel human leukocyte- and platelet- rich concentrate
(University of the Western Cape, 2018)
Wound healing is a complex process that involves several overlapping and
interacting biological pathways. The consequences of delayed or abnormal
wound healing may result in tissue formation that has impaired function ...
Radioprotective effects of rooibos herbal tea on the developing central nervous system of wistar rats
(University of the Western Cape, 2018)
Background: Early postnatal radiation exposure from environmental, diagnostic or therapeutic
sources is potentially deleterious to the developing nervous system resulting in oxidative stress,
structural damage, altered ...