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Now showing items 11-14 of 14
The role of the glutathione system in regulating the levels of ROS neutralisation in the endothelial cells of the blood-brain barrier
(University of the Western Cape, 2017)
Brain endothelial cell types are frequently used as in vitro models to study the
blood-brain barrier (BBB). Oxidative stress (OS) has been reported numerous times
to cause BBB dysfunction which is crucial to the initiation ...
The role of arylamine N-acetyltransferase 1 (NAT1) in the clinical therapy of tuberculosis
(University of the Western Cape, 2017)
Despite attempts to develop new drugs to reduce the worldwide mortality rate attributable to
tuberculosis (TB), the illness remains a threat. Isoniazid (INH) has been used as a frontline
drug for decades. However, several ...
The effects of selective inhibitors of N-Glycosylation and Endoplasmic Reticulum stress inducers on Neuroblastoma cell proliferation and Apoptosis
(University of the Western Cape, 2017)
Among all childhood cancers diagnosed, neuroblastoma (NB) is the most prevalent during
infancy. In patients younger than 15 years, it accounts for more than 7% of malignancies and
about 15% of all paediatric mortalities. ...
The Generation of Antibodies against Human Coronavirus NL63 (HCoV-NL63) Nucleocapsid Protein
(University of the Western Cape, 2017)
Coronaviruses (CoVs) are enveloped viruses composed of single-stranded, positive sense
RNA viruses with the largest viral genomes among RNA viruses (27-33 kb). In 2004,
human coronavirus NL63 (HCoV-NL63) was discovered by ...